CAJ | 학술논문

目的：探讨天雄补肾助阳药效机理，为进一步研究开发炮天雄治肾阳虚证新药提供实验依据。方法：采用常规阳虚证和肾虚证动物模型，观察低温游泳存活时间、脏器系数、阴茎勃起潜伏期等指标。结果：炮天雄煎剂能提高阳虚证小鼠耐疲劳能力，延长其低温存活时间，促进肾虚证大鼠免疫作用。结论：炮天雄具有一定的补肾助阳功效，与其历代文献记载“补命门、强肾气”和现在港澳中医临床治疗肾亏阳虚证相吻合。
목적：탐토천웅보신조양약효궤리，위진일보연구개발포천웅치신양허증신약제공실험의거。방법：채용상규양허증화신허증동물모형，관찰저온유영존활시간、장기계수、음경발기잠복기등지표。결과：포천웅전제능제고양허증소서내피로능력，연장기저온존활시간，촉진신허증대서면역작용。결론：포천웅구유일정적보신조양공효，여기역대문헌기재“보명문、강신기”화현재항오중의림상치료신우양허증상문합。
Objective: To explore the pharmacodynamic mechanism of Tianxiong (Aconitum carmichaeli) in tonifying the kidney and supporting Yang, so as to provide evidences for further development of new drugs treating Yang-eficiency of the kidney. Method: Observing parameters such as visceral index, survival time of low-temperature swimming for hydrocortisone-induced Yang-deficiency model mouse and testis-removed kidney-deficiency model rat. Result: The decoction of processed Tianxiong could strengthen the antifatigual ability and prolong the survival time of low-temperature swimming for mice, and promote immunization in rats. Conclusion: Tianxiong is able to reinforce the kidney Yang, which reconforms the conclusion of “replenishing the fire of vital gate and the Qi of kidney" recorded in Chinese historical literature and proved by overseas clinical practice.