CAJ | 학술논문

Survivin是凋亡抑制蛋白(inhibitor of apoptosis protein,IAP)家族中结构独特的新成员,特异性高表达于大多数肿瘤组织中.Survivin表达调控主要在转录水平,多个转录因子(如P53、Sp1等)参与survivin转录调节,并有不同的信号转导分子参与.了解survivin表达的调控机制,对于肿瘤的靶向治疗有十分重要的意义.
Survivin시조망억제단백(inhibitor of apoptosis protein,IAP)가족중결구독특적신성원,특이성고표체우대다수종류조직중.Survivin표체조공주요재전록수평,다개전록인자(여P53、Sp1등)삼여survivin전록조절,병유불동적신호전도분자삼여.료해survivin표체적조공궤제,대우종류적파향치료유십분중요적의의.
Survivin is a new and structurally unique member of the inhibitor of apoptosis protein discovered in recent years,which is highly expressed specifically in most neoplasms.The regulation of survivin expression occurs mainly at transcription levels,and there are several transcription factors such as P53 and Sp1 involved in the regulation of survivin expression.Several signal transduction factors are involved in it else.Knowledge of the regulation mechanism of survivin expression is crucial for the targetting therapy of tumors.