国际呼吸杂志
國際呼吸雜誌
국제호흡잡지
INTERNATIONAL JOURNAL OF RESPIRATION
2012年
5期
321-326
,共6页
关伟杰%郑劲平%蒋才玉%谢燕清%安嘉颖%虞欣欣%刘文婷%高怡
關偉傑%鄭勁平%蔣纔玉%謝燕清%安嘉穎%虞訢訢%劉文婷%高怡
관위걸%정경평%장재옥%사연청%안가영%우흔흔%류문정%고이
呼出气一氧化氮%支气管哮喘%哮喘控制状态%诊断价值
呼齣氣一氧化氮%支氣管哮喘%哮喘控製狀態%診斷價值
호출기일양화담%지기관효천%효천공제상태%진단개치
Fractional exhaled nitric oxide%Bronchial asthma%Asthma control%Diagnostic value
目的 比较呼出气一氧化氮(FeNO)浓度测定在不同控制状态支气管哮喘(简称哮喘)FeNO患者中的差异.方法 使用瑞典Aerocrine NIOX MINO测试仪对83例受试者(20例未控制、22例部分控制、20例完全控制哮喘患者和21名正常受试者)进行FeNO浓度测定,分析各组数据的分布特点以及与AQLQ哮喘症状评分的相关关系,并通过受试者工作特征图探讨对不同哮喘控制状态气道炎症增高的识别能力.结果 未控制组与部分控制组(26.0~49.0)区间的比例(分别为40.0%与40.9%)高于完全控制组(25.0%),但差异无统计学意义(x2=1.421,P=0.491),未控制组个体间差异最大.部分控制组(41.0 ppb)与未控制组的中位数(45.5 ppb)相近,完全控制组(57.5 ppb)最大,但三组间差异无统计学意义(x2 =0.971,P=0.615).FeNO与AQLQ哮喘症状评分之间不存在相关关系(r =-0.084,P>0.05).FeNO测定对不同哮喘控制状态增高的气道炎症识别能力相当(AUC>0.75,P<0.05),对未控制与部分控制患者识别能力稍优于完全控制患者.结论 哮喘控制状态与FeNO不平行,FeNO测定对不同哮喘控制状态气道炎症的识别能力接近,但不能作为判断控制状态的单独依据.
目的 比較呼齣氣一氧化氮(FeNO)濃度測定在不同控製狀態支氣管哮喘(簡稱哮喘)FeNO患者中的差異.方法 使用瑞典Aerocrine NIOX MINO測試儀對83例受試者(20例未控製、22例部分控製、20例完全控製哮喘患者和21名正常受試者)進行FeNO濃度測定,分析各組數據的分佈特點以及與AQLQ哮喘癥狀評分的相關關繫,併通過受試者工作特徵圖探討對不同哮喘控製狀態氣道炎癥增高的識彆能力.結果 未控製組與部分控製組(26.0~49.0)區間的比例(分彆為40.0%與40.9%)高于完全控製組(25.0%),但差異無統計學意義(x2=1.421,P=0.491),未控製組箇體間差異最大.部分控製組(41.0 ppb)與未控製組的中位數(45.5 ppb)相近,完全控製組(57.5 ppb)最大,但三組間差異無統計學意義(x2 =0.971,P=0.615).FeNO與AQLQ哮喘癥狀評分之間不存在相關關繫(r =-0.084,P>0.05).FeNO測定對不同哮喘控製狀態增高的氣道炎癥識彆能力相噹(AUC>0.75,P<0.05),對未控製與部分控製患者識彆能力稍優于完全控製患者.結論 哮喘控製狀態與FeNO不平行,FeNO測定對不同哮喘控製狀態氣道炎癥的識彆能力接近,但不能作為判斷控製狀態的單獨依據.
목적 비교호출기일양화담(FeNO)농도측정재불동공제상태지기관효천(간칭효천)FeNO환자중적차이.방법 사용서전Aerocrine NIOX MINO측시의대83례수시자(20례미공제、22례부분공제、20례완전공제효천환자화21명정상수시자)진행FeNO농도측정,분석각조수거적분포특점이급여AQLQ효천증상평분적상관관계,병통과수시자공작특정도탐토대불동효천공제상태기도염증증고적식별능력.결과 미공제조여부분공제조(26.0~49.0)구간적비례(분별위40.0%여40.9%)고우완전공제조(25.0%),단차이무통계학의의(x2=1.421,P=0.491),미공제조개체간차이최대.부분공제조(41.0 ppb)여미공제조적중위수(45.5 ppb)상근,완전공제조(57.5 ppb)최대,단삼조간차이무통계학의의(x2 =0.971,P=0.615).FeNO여AQLQ효천증상평분지간불존재상관관계(r =-0.084,P>0.05).FeNO측정대불동효천공제상태증고적기도염증식별능력상당(AUC>0.75,P<0.05),대미공제여부분공제환자식별능력초우우완전공제환자.결론 효천공제상태여FeNO불평행,FeNO측정대불동효천공제상태기도염증적식별능력접근,단불능작위판단공제상태적단독의거.
Objective To compare the distinction in fractional exhaled nitric oxide (FeNO) in asthmatics under different control statuses.Methods Measurements of FeNO were performed in 20 uncontrolled,22 partly controlled and 20 controlled asthmatics and 21 normal controls using a portable NIOX MINO detector (Aerocrine Co.Ltd.,Sweden).The distribution character of FeNO in each group was analyzed,and the correlation with AQLQ asthma symptom score was determined.The discriminative power to enhanced airway inflammation was compared using receiver operation characteristic curve.Results The proportion of FeNO between 26.0 ppb and 49.0 ppb was larger in uncontrolled (40.0%) and partly controlled (40.9 %) asthmatics as compared with that of controlled asthmatics (25.0%),though no statistical difference (x2 =1.421,P =0.491) was found.Interpersonal variation was highest in uncontrolled asthmatics.The median of partly controlled group (41.0 ppb) resembled that of uncontrolled group (45.5 ppb),both of which were lower than that of controlled group (57.5 ppb),with no statistical significance ( x2 =0.971,P =0.615) shown in their difference.No correlation ( r =-0.084,P>0.05) between overall level of FeNO and AQLQ asthma symptom score was revealed.Measurement of FeNO had discriminative power to asthmatics under various control statuses ( AUC > 0.75,P < 0.05) as reflected by receiver operation characteristic curves,with minor superiority in uncontrolled and partly controlled asthmatics.Conclusions FeNO is unparallel to asthma control.Measurement of FeNO is of discriminative power to enhanced airway inflammation in asthmatics under different control statuses,despite that it could not be regarded as the single predictor of asthma control.