中华行为医学与脑科学杂志
中華行為醫學與腦科學雜誌
중화행위의학여뇌과학잡지
CHINESE JOURNAL OF BEHAVIORAL MEDICINE AND BRAIN SCIENCE
2010年
12期
1099-1101
,共3页
洪芬芳%贺长生%涂桂林%杨树龙
洪芬芳%賀長生%塗桂林%楊樹龍
홍분방%하장생%도계림%양수룡
人参皂甙%快动眼睡眠%非快动眼睡眠%脑电图
人參皂甙%快動眼睡眠%非快動眼睡眠%腦電圖
인삼조대%쾌동안수면%비쾌동안수면%뇌전도
Ginsenosides%Rapid eye movement%Non rapid eye movement%Electroencephalogram
目的 研究人参皂甙(GS)调节自发睡眠结构和皮质脑电功率谱的作用.方法 SD大鼠24只随机分为对照、低(GS 10mg/kg)和高剂量(100mg/kg)组,每组8只.大鼠体内植入无线发射器,手术后按10和100mg/kgGS或蒸馏水给大鼠灌胃,每日1次共6天.在给药第1和6天记录自由活动大鼠脑电(EEG)活动12 h.结果 GS灌胃第1天,仅高剂量增加了总睡眠和非快动眼睡眠(NREM)而减少觉醒[(9.40±0.88)h,(8.00±1.21)h,(2.46±0.81)hs(7.55±1.59)h,(6.36±1.54)h,(4.38±1.62)h,(P＜0.05或P＜0.01)];低、高剂量GS增强了NREM和觉醒δ波功率(P＜0.05),但减少觉醒θ波功率(P＜0.01)以及NREM、REM睡眠和觉醒波功率(P＜0.01),低、高剂量GS分别降低REM和NREM的θ波功率(P＜0.05).灌胃第6天,低、高剂量GS显著增加总睡眠(P＜0.05)和NREM(P＜0.05),降低觉醒(P＜0.05)和睡眠/觉醒周期(P＜0.05);低、高剂量GS增强NREM和觉醒δ波功率(P＜0.05),减少觉醒θ波功率(P＜0.05)以及NREM、NEM睡眠和觉醒波功率(P＜0.05),低剂量GS还降低NREM睡眠θ波功率(P＜0.01).结论 GS能时间依赖性调节大鼠自发睡眠结构,以及具有广泛调节皮层脑电功率谱的作用.
目的 研究人參皂甙(GS)調節自髮睡眠結構和皮質腦電功率譜的作用.方法 SD大鼠24隻隨機分為對照、低(GS 10mg/kg)和高劑量(100mg/kg)組,每組8隻.大鼠體內植入無線髮射器,手術後按10和100mg/kgGS或蒸餾水給大鼠灌胃,每日1次共6天.在給藥第1和6天記錄自由活動大鼠腦電(EEG)活動12 h.結果 GS灌胃第1天,僅高劑量增加瞭總睡眠和非快動眼睡眠(NREM)而減少覺醒[(9.40±0.88)h,(8.00±1.21)h,(2.46±0.81)hs(7.55±1.59)h,(6.36±1.54)h,(4.38±1.62)h,(P＜0.05或P＜0.01)];低、高劑量GS增彊瞭NREM和覺醒δ波功率(P＜0.05),但減少覺醒θ波功率(P＜0.01)以及NREM、REM睡眠和覺醒波功率(P＜0.01),低、高劑量GS分彆降低REM和NREM的θ波功率(P＜0.05).灌胃第6天,低、高劑量GS顯著增加總睡眠(P＜0.05)和NREM(P＜0.05),降低覺醒(P＜0.05)和睡眠/覺醒週期(P＜0.05);低、高劑量GS增彊NREM和覺醒δ波功率(P＜0.05),減少覺醒θ波功率(P＜0.05)以及NREM、NEM睡眠和覺醒波功率(P＜0.05),低劑量GS還降低NREM睡眠θ波功率(P＜0.01).結論 GS能時間依賴性調節大鼠自髮睡眠結構,以及具有廣汎調節皮層腦電功率譜的作用.
목적 연구인삼조대(GS)조절자발수면결구화피질뇌전공솔보적작용.방법 SD대서24지수궤분위대조、저(GS 10mg/kg)화고제량(100mg/kg)조,매조8지.대서체내식입무선발사기,수술후안10화100mg/kgGS혹증류수급대서관위,매일1차공6천.재급약제1화6천기록자유활동대서뇌전(EEG)활동12 h.결과 GS관위제1천,부고제량증가료총수면화비쾌동안수면(NREM)이감소각성[(9.40±0.88)h,(8.00±1.21)h,(2.46±0.81)hs(7.55±1.59)h,(6.36±1.54)h,(4.38±1.62)h,(P＜0.05혹P＜0.01)];저、고제량GS증강료NREM화각성δ파공솔(P＜0.05),단감소각성θ파공솔(P＜0.01)이급NREM、REM수면화각성파공솔(P＜0.01),저、고제량GS분별강저REM화NREM적θ파공솔(P＜0.05).관위제6천,저、고제량GS현저증가총수면(P＜0.05)화NREM(P＜0.05),강저각성(P＜0.05)화수면/각성주기(P＜0.05);저、고제량GS증강NREM화각성δ파공솔(P＜0.05),감소각성θ파공솔(P＜0.05)이급NREM、NEM수면화각성파공솔(P＜0.05),저제량GS환강저NREM수면θ파공솔(P＜0.01).결론 GS능시간의뢰성조절대서자발수면결구,이급구유엄범조절피층뇌전공솔보적작용.
Objective To study the effects of ginsenosides (GS) on spontaneous sleep architecture and Cortical EEG power spectrum. Methods 24 adult SD rats were randomly divided into the control, GS 10 and 100mg/kg groups ( n = 8). Rats were instrumented with sleep-wake recording electrodes. After recovery from surgical operation,rats were orally administered GS 10 and 100mg/kg or distilled water once per day for 6 days. On GS administration day 1 and 6,Polygraphic signs of undisturbed sleep-wake activities were recorded for 12 h after GS administration. Results On GS administration day 1 ,only 100mg/kg GS increased significantly total sleep and the non-rapid eye movement ( NREM ) sleep but decreased wakefulness [(9.40 ± 0.88 ) h, ( 8.00 ± 1. 21 ) h,(2.46 ±0.81)h s (7.55 ±1.59)h,(6.36±1.54)h,(4.38 ±1.62)h,(P＜0.01, P＜0.05, P＜0.01),respectively] ;Low and high dose GS enhanced δ-wave power of NREM sleep and wakefulness (P＜ 0.05 ) but reduced θ-wave power of wakefulness (P＜0.01) and-wave power during NREM, REM sleep and wakefulness (P ＜ 0.01 ),moreover,Low and high dose GS lowered θ-wave power of REM and NREM stage(P＜0.05 ) ,respectively. After 6days of GS administration, Low and high dose GS increased markedly total sleep(P＜0.05 ) and NREM sleep(P＜0.05 ) but decreased wakefulness (P ＜0.05 ) and sleep-wake cycles (P ＜ 0.05, P ＜ 0.01 ); moreover, Low and high dose GS enhanced δ-wave power during NREM sleep and wakefulness (P ＜ 0. 05 ) but reduced θ-wave power of wakefulness(P ＜ 0.05 ) and -wave power during NREM, NEM sleep and wakefulness (P ＜ 0. 05 ), 10mg/kg GS also lowered θ-wave power of NREM sleep (P＜0.01). Conclusion These results demonstrate that GS can regulate spontaneous sleep architecture in time dependent manner,as well as cortical EEG power spectrum in rats.
