CAJ | 학술논문

腺苷是机体内一种重要的生物活性物质，其广泛存在于细胞内液和细胞外液中。在生理状态下，细胞内外的腺苷浓度较低，但在应激情况下，如炎症、缺血、缺氧、创伤、疼痛等，机体内腺苷浓度会大幅度上升，广泛参与多种病理变化过程。腺苷受体具有A1、A2A、A2B、A3 4种亚型。腺苷通过其受体调控细胞的各种生理功能。目前研究发现腺苷在机体的中枢神经系统、心血管系统、凝血系统等发挥重要作用。近几年来，腺苷在眼部，特别是青光眼、视网膜疾病治疗方面的作用受到广泛关注。腺苷在眼部的作用表现为调节眼压、抑制视网膜新生血管、舒张视网膜血管、调节视网膜神经传导、保护视网膜光感受器和视网膜神经节细胞(RGCs)、抑制炎症反应等。就腺苷和其受体、生物制剂的研究进展及其在眼科的应用前景进行综述。
선감시궤체내일충중요적생물활성물질，기엄범존재우세포내액화세포외액중。재생리상태하，세포내외적선감농도교저，단재응격정황하，여염증、결혈、결양、창상、동통등，궤체내선감농도회대폭도상승，엄범삼여다충병리변화과정。선감수체구유A1、A2A、A2B、A3 4충아형。선감통과기수체조공세포적각충생리공능。목전연구발현선감재궤체적중추신경계통、심혈관계통、응혈계통등발휘중요작용。근궤년래，선감재안부，특별시청광안、시망막질병치료방면적작용수도엄범관주。선감재안부적작용표현위조절안압、억제시망막신생혈관、서장시망막혈관、조절시망막신경전도、보호시망막광감수기화시망막신경절세포(RGCs)、억제염증반응등。취선감화기수체、생물제제적연구진전급기재안과적응용전경진행종술。
Adenosine is an important biological substance in the body. It exists extensively in intracellular and extracellular tissues. In physiological condition, adenosine remains at very low level intissue. However, under stress such as inflammation, ischemia, hypoxia, trauma, or pain etc. the adenosine concentration will be elevated dramatically,indicating that adenosine participates in multiple histopathological processes. Adenosine is a natural chemical messenger that binds to four subtypes( A1, A2A, A2B, A3 ) of adenosine receptors and by that, it regulates multiple kinds of physiological functions. Studies found that adenosine plays an important role in the central nervous system, cardiovascular system and coagulation system. In recent years, adenosine has been seen as an attractive option to improve the treatment of glaucoma and retinal diseases. The effects of adenosine in ophthalmology were as follows: adjusting intraocular pressure, inhibiting retinal angiogenesis, dilating retinal blood vessels, regulating retinal nerve conduction, protecting retinal photoreceptors and ganglion cells, arresting the inflammatory response. This article discusses the research progress in adenosine and its receptors as well as biological products of adenosine and projects the application of adenosine in ophthalmology.