中国实用眼科杂志
中國實用眼科雜誌
중국실용안과잡지
CHINESE JOURNAL OF PRACTICAL OPHTHALMOLOGY
2012年
9期
1040-1044
,共5页
糖尿病性视网膜病变%激光治疗%光学相干断层扫描%多焦视网膜电图
糖尿病性視網膜病變%激光治療%光學相榦斷層掃描%多焦視網膜電圖
당뇨병성시망막병변%격광치료%광학상간단층소묘%다초시망막전도
Diabetic retinopathy%Laser photocoagulation%Optical coherence tomography%Multifocal electroretinogram
目的 应用光学相干断层扫描(optical coherence tomography,OCT)联合多焦视网膜电图(multifocal electroretinogram,mfERG)观察多点扫描矩阵激光全视网膜光凝治疗重度非增殖性糖尿病视网膜病变(severe non-proliferative diabetic retinopathy,severe NPDR)及增殖性糖尿病视网膜病变(proliferative diabetic retinopathy,PDR)后激光对视网膜组织结构及视网膜功能的影响.方法 临床病例对照研究.对2010年4～11月在天津市眼科医院就诊的53例(64只眼)DR患者随机分为多点扫描矩阵激光(实验组)；传统多波长氪黄激光组(对照组).随访时间3个月,光凝前进行最佳矫正视力(the best corrected visual acuity,BCVA)、裂隙灯生物显微镜、眼底、眼底荧光血管造影(fudus fluorescein angiography,FFA)、OCT及mfERG检查,术后1周、1月、3月进行BCVA、OCT及mfERG检查.比较两组异同.结果 激光术后两组黄斑中心凹厚度均出现明显增加,但两组差异无统计学意义(F值=20.722和23.752,P＞0.05).两组P1波、N1波振幅密度均出现不同程度下降,术后1周下降最显著,术后1～3月逐渐恢复,术后对照组各波振幅密度下降幅度较实验组明显且恢复速度慢.结论 本研究证实多点扫描矩阵激光与氪黄激光在治疗糖尿病视网膜病变上疗效相同,并对视网膜功能损伤较小.
目的 應用光學相榦斷層掃描(optical coherence tomography,OCT)聯閤多焦視網膜電圖(multifocal electroretinogram,mfERG)觀察多點掃描矩陣激光全視網膜光凝治療重度非增殖性糖尿病視網膜病變(severe non-proliferative diabetic retinopathy,severe NPDR)及增殖性糖尿病視網膜病變(proliferative diabetic retinopathy,PDR)後激光對視網膜組織結構及視網膜功能的影響.方法 臨床病例對照研究.對2010年4～11月在天津市眼科醫院就診的53例(64隻眼)DR患者隨機分為多點掃描矩陣激光(實驗組)；傳統多波長氪黃激光組(對照組).隨訪時間3箇月,光凝前進行最佳矯正視力(the best corrected visual acuity,BCVA)、裂隙燈生物顯微鏡、眼底、眼底熒光血管造影(fudus fluorescein angiography,FFA)、OCT及mfERG檢查,術後1週、1月、3月進行BCVA、OCT及mfERG檢查.比較兩組異同.結果 激光術後兩組黃斑中心凹厚度均齣現明顯增加,但兩組差異無統計學意義(F值=20.722和23.752,P＞0.05).兩組P1波、N1波振幅密度均齣現不同程度下降,術後1週下降最顯著,術後1～3月逐漸恢複,術後對照組各波振幅密度下降幅度較實驗組明顯且恢複速度慢.結論 本研究證實多點掃描矩陣激光與氪黃激光在治療糖尿病視網膜病變上療效相同,併對視網膜功能損傷較小.
목적 응용광학상간단층소묘(optical coherence tomography,OCT)연합다초시망막전도(multifocal electroretinogram,mfERG)관찰다점소묘구진격광전시망막광응치료중도비증식성당뇨병시망막병변(severe non-proliferative diabetic retinopathy,severe NPDR)급증식성당뇨병시망막병변(proliferative diabetic retinopathy,PDR)후격광대시망막조직결구급시망막공능적영향.방법 림상병례대조연구.대2010년4～11월재천진시안과의원취진적53례(64지안)DR환자수궤분위다점소묘구진격광(실험조)；전통다파장극황격광조(대조조).수방시간3개월,광응전진행최가교정시력(the best corrected visual acuity,BCVA)、렬극등생물현미경、안저、안저형광혈관조영(fudus fluorescein angiography,FFA)、OCT급mfERG검사,술후1주、1월、3월진행BCVA、OCT급mfERG검사.비교량조이동.결과 격광술후량조황반중심요후도균출현명현증가,단량조차이무통계학의의(F치=20.722화23.752,P＞0.05).량조P1파、N1파진폭밀도균출현불동정도하강,술후1주하강최현저,술후1～3월축점회복,술후대조조각파진폭밀도하강폭도교실험조명현차회복속도만.결론 본연구증실다점소묘구진격광여극황격광재치료당뇨병시망막병변상료효상동,병대시망막공능손상교소.
Objective To investigate the effects of pan-retinal photocoagulation (PRP) with supra scan laser on the severe non-proliferative diabetic retinopathy and to analyze the affect of retinal structure and function after laser photocoagulation by optical coherence tomography (OCT) and multifocal electroretinogram (mfERG).Methods Sixty-four eyes of 53 severe non-proliferative diabetic retinopathy patients were assigned randomly to receive either supra scan laser or krypton yellow laser treatment.Follow up examinations were performed 3 months,the best corrected visual acuity (BCVA),slit-lamp biomicroscopy,ophthalmoscopy,fudus fluorescein angiography (FFA),OCT and mfERG were performed before treatment.One week,1 month,3 months after treatment,BCVA,OCT and mfERG were examined.The differences between two groups were compared.Results The central subfield thickness increased in both groups after treatment,there was especially obvious increase in the control group,there was no statistical difference in both group (P ＞0.05),the P1,N1 waves amplitude had various loss and reached the lowest level at 1 week after treatment and recovered gradually from 1 month to 3 months after treatment,the amplitude of control group decreased more significantly and recovered more slowly compared to the test group.Conclusions Supra scan laser photocoagulation for DR is as effective as krypton yellow laser,and reduces the damage at the same time.
