中国保健营养(上旬刊)
中國保健營養(上旬刊)
중국보건영양(상순간)
China Health Care & Nutrition
2014年
4期
2261-2262
,共2页
缓冲剂%盐酸氨溴索组合物%稳定性%注射液
緩遲劑%鹽痠氨溴索組閤物%穩定性%註射液
완충제%염산안추색조합물%은정성%주사액
Buffer solution%Ambroxol hydrochloride compound%Stability%Injection
以添加柠檬酸和枸橼酸钠为缓冲剂,制备了组分简单的盐酸氨溴索组合物,并进一步制备了盐酸氨溴索组合物注射液。实验结果显示,该注射液在比较高的pH(5.5-7.0)条件下,活性药物盐酸氨溴索的稳定性较高,更适合人体注射,可以明显减少注射时给患者带来的不适感。
以添加檸檬痠和枸櫞痠鈉為緩遲劑,製備瞭組分簡單的鹽痠氨溴索組閤物,併進一步製備瞭鹽痠氨溴索組閤物註射液。實驗結果顯示,該註射液在比較高的pH(5.5-7.0)條件下,活性藥物鹽痠氨溴索的穩定性較高,更適閤人體註射,可以明顯減少註射時給患者帶來的不適感。
이첨가저몽산화구연산납위완충제,제비료조분간단적염산안추색조합물,병진일보제비료염산안추색조합물주사액。실험결과현시,해주사액재비교고적pH(5.5-7.0)조건하,활성약물염산안추색적은정성교고,경괄합인체주사,가이명현감소주사시급환자대래적불괄감。
By adding citric acid and natrium citricum trihydrate as buffer solution ,ambroxol hydrochloride compound with simple component was prepared ,which further to be made into form of injection.Related results indicated that be alive pharmacy material of injection showed higher stability under high pH range from 5.5 to 7.0,which is more suitable for human injection,resulting in fewer uneasy feeling for patient.