化学工程师
化學工程師
화학공정사
CHEMICAL ENGINEER
2009年
7期
67-68
,共2页
香兰素%溴化反应%合成%5-溴香兰素
香蘭素%溴化反應%閤成%5-溴香蘭素
향란소%추화반응%합성%5-추향란소
vanillin%bromination%synthesis%5-bromo-vanillin
以冰醋酸为溶剂,香兰素为原料,AlBr3为催化剂,HBrO3与KBrO3为溴化剂合成了5-溴香兰素.采用正交实验法考察了影响收率的因素.最佳条件为:香兰素、KBrO3与AlBr3的物质的量的摩尔比为1:0.5:0.056,反应时间6.0h,反应温度30℃.在优化条件下收率可达90.4%.产物结构通过IR、1HNMR、熔点测定和元素分析得以确认.
以冰醋痠為溶劑,香蘭素為原料,AlBr3為催化劑,HBrO3與KBrO3為溴化劑閤成瞭5-溴香蘭素.採用正交實驗法攷察瞭影響收率的因素.最佳條件為:香蘭素、KBrO3與AlBr3的物質的量的摩爾比為1:0.5:0.056,反應時間6.0h,反應溫度30℃.在優化條件下收率可達90.4%.產物結構通過IR、1HNMR、鎔點測定和元素分析得以確認.
이빙작산위용제,향란소위원료,AlBr3위최화제,HBrO3여KBrO3위추화제합성료5-추향란소.채용정교실험법고찰료영향수솔적인소.최가조건위:향란소、KBrO3여AlBr3적물질적량적마이비위1:0.5:0.056,반응시간6.0h,반응온도30℃.재우화조건하수솔가체90.4%.산물결구통과IR、1HNMR、용점측정화원소분석득이학인.
5-bromo-vanillin was synthesizedby using vanillin as raw material,aluminium chloride as catalyst, hydrobromic acid and potassium bromate as brominating agent and acetic acid as solvent.Factors influencing the yield were investigated by the orthogonal experimental method.The optimum conditions are as follows:Vanillin: potassium bromate:aluminium chloride is 1mol:0.5mol:0.056mol, reaction time is 6.0h,reaction temperature is 30%. The yield is above 90.4% under the optimum conditions. The title compound was characterized by IR,1H NMR,mp. Measurement and element analysis.
