中国神经再生研究（英文版）
中國神經再生研究（英文版）
중국신경재생연구（영문판）
NERVE REGENERATION RESEARCH
2011年
30期
2325-2331
,共7页
Alzheimer's disease%endoplasmic reticulum stress%Fructus Broussonetiae extract%beta-amyloid peptide 25-35%D-galactose%recognition%neural regeneration
This study investigated the effects and possible targets of Fructus Broussonetiae extract, a traditional Chinese medicinal herb, on a model of Alzheimer's disease induced by beta-amyloid peptide 25-35 and D-galactose. The results revealed that intragastric administration of Fructus Broussonetiae significantly increased the expression of immunoglobulin-binding protein, a key factor in the endoplasmic reticulum stress-signaling pathway in rat hippocampus. In contrast, the treatment significantly decreased expression levels of PKR-like endoplasmic reticulum kinase and C/EBP homologous protein, and substantially improved learning, memory and spatial recognition dysfunction in rats. This evidence indicates that Fructus Broussonetiae extract improves spatial learning and memory abilities in rats by affecting the regulation of hippocampal endoplasmic reticulum stress and activation of the apoptosis pathway.
