CAJ | 학술논문

目的探讨绝经后2型糖尿病(T2DM)患者骨质疏松的相关因素.方法采用双能X线骨密度仪测定79例绝经后T2DM患者的正位腰椎(L1-4)、左股骨颈与左股骨粗隆及左全髋骨密度,根据骨密度值分为骨质疏松组与非骨质疏松组,并对测定的相关化验指标、年龄、病程、绝经年龄、绝经年限及体质指数(BMI)等进行对比分析.结果两组年龄、BMI、白细胞介素6(IL-6)、骨钙素、绝经年限差异均有统计学意义,直线相关分析显示IL-6与骨质疏松(r=0.260,P=0.020)及糖化血红蛋白(GHbAlc)(r=0.259,P=0.023)相关;Logistic多因素回归分析显示,绝经后T2DM患者骨质疏松的发生与年龄独立相关,与BMI独立负相关.结论年龄与低BMI可能是绝经后T2DM患者骨质疏松发生的独立危险因素.
목적 탐토절경후2형당뇨병(T2DM)환자골질소송적상관인소.방법 채용쌍능X선골밀도의측정79례절경후T2DM환자적정위요추(L1-4)、좌고골경여좌고골조륭급좌전관골밀도,근거골밀도치분위골질소송조여비골질소송조,병대측정적상관화험지표、년령、병정、절경년령、절경년한급체질지수(BMI)등진행대비분석.결과 량조년령、BMI、백세포개소6(IL-6)、골개소、절경년한차이균유통계학의의,직선상관분석현시IL-6여골질소송(r=0.260,P=0.020)급당화혈홍단백(GHbAlc)(r=0.259,P=0.023)상관;Logistic다인소회귀분석현시,절경후T2DM환자골질소송적발생여년령독립상관,여BMI독립부상관.결론 년령여저BMI가능시절경후T2DM환자골질소송발생적독립위험인소.
Objective To investigate the morbidity and related factors for osteoporosis in postmenopausal patients with type 2 diabetes mellitus (T2DM).Methods The bone mineral density (BMD) at lumbar vertebrae(L1-4), left femoral neck, femoral trochanter and total hip were measured by dual energy X-ray absorptiometry (DEXA) in 79 postmenopansal patients with T2DM.The patients were divided into two groups: osteoporosis group and non-osteoporosis group.The correlations between BMD and age, course of disease, menopausal age, menopausal duration and body mass index (BMI) were analyzed by multivariate regression analysis.Results There were significantly statistical differences in age, BMI, interleukin 6 (IL-6), osteocalcin and menopause duration between two groups.Linear correlation analysis showed IL-6 was positively correlated with osteoporosis (r=0.260, P=0.020) and glycosylated hemoglobin (GHbAlc) (r=0.259, P=0.023) Logistic regression analysis showed that the morbidity of osteoporosis had an independent positive correlation with age, but an independent negative correlation with BMI.Conclusions In postmenopausal patients with T2DM, age and low BMI are independent risk factors for osteoporosis.