河北化工
河北化工
하북화공
HEBEI CHEMICAL ENGINEERING AND INDUSTRY
2012年
1期
22-23
,共2页
(2-噻吩基甲基)丙二酸单甲酯%2-噻吩甲醛%丙二酸二乙酯%依普罗沙坦%中间体%制备
(2-噻吩基甲基)丙二痠單甲酯%2-噻吩甲醛%丙二痠二乙酯%依普囉沙坦%中間體%製備
(2-새분기갑기)병이산단갑지%2-새분갑철%병이산이을지%의보라사탄%중간체%제비
2-carbethoxy-3-(2-thienyl)propanoic acid%2-thiophenealdehyde%diethyl malonate%Eprosartan%intermediate%preparation
(2-噻吩基甲基)丙二酸单甲酯为合成依普罗沙坦的关键中间体,以2-噻吩甲醛、丙二酸二乙酯为主要原料,通过加成、消除、水解反应制备而得。
(2-噻吩基甲基)丙二痠單甲酯為閤成依普囉沙坦的關鍵中間體,以2-噻吩甲醛、丙二痠二乙酯為主要原料,通過加成、消除、水解反應製備而得。
(2-새분기갑기)병이산단갑지위합성의보라사탄적관건중간체,이2-새분갑철、병이산이을지위주요원료,통과가성、소제、수해반응제비이득。
2-Carbethoxy-3-(2-thienyl)propanoic acid is a key intermediate of Eprosartan.It was prepared with 2-thiophene- aldehyde, diethyl malonate as the main materials, through the addition, elimination and hydrolysis reaction.