中国医师杂志
中國醫師雜誌
중국의사잡지
JOURNAL OF CHINESE PHYSICIAN
2010年
7期
879-882
,共4页
雄激素类/缺乏%骨密度%危险因素%综合征
雄激素類/缺乏%骨密度%危險因素%綜閤徵
웅격소류/결핍%골밀도%위험인소%종합정
Androgens/DF%Bone density%Risk factors%Syndrome
目的 探讨中老年男性雄激素部分缺乏综合征(partial androgen deficiency in the aging male,PADAM)患者的骨密度(bone mineral density,BMD)特点及其影响因素.方法 采用双能X线骨密度仪(dual energy X-ray absorptiometry,DEXA)测定186例中老年PADAM患者和125例年龄、体重指数(body mass index,BMI)相匹配的健康中老年人的腰椎及股骨颈骨密度,收集相关生化、性激素及骨代谢指标,并对其与年龄、身高、体重、BMI、性激素水平及部分骨代谢指标进行多元逐步回归分析.结果 (1)PADAM组患者腰椎BMD与健康对照组差异无统计学意义(P＞0.05),但股骨颈各部位BMD均较健康对照组明显降低[Neck:(0.831±0.136)g/cm2 vs(0.954±0.143)g/cm2,Ward's:(0.712±0.127)g/cm2 vs(0.811±0.149)g/cm2,Troch:(0.697±0.124)g/cm2 vs(0.764±0.131)g/cm2,P＜0.05)].(2)PADAM组及健康对照组骨量减少的发生率分别为48.9%、36%,骨质疏松的发生率分别为33.3%、20.8%.(3)PADAM患者腰椎BMD与BMI呈正相关;而股骨颈各部位BMD均与年龄呈负相关,与BMI、雄激素水平呈正相关(P＜0.05).结论 PADAM患者股骨颈各部位骨密度明显降低.高龄、低体重指数和低雄激素水平为PADAM患者BMD降低的危险因素.
目的 探討中老年男性雄激素部分缺乏綜閤徵(partial androgen deficiency in the aging male,PADAM)患者的骨密度(bone mineral density,BMD)特點及其影響因素.方法 採用雙能X線骨密度儀(dual energy X-ray absorptiometry,DEXA)測定186例中老年PADAM患者和125例年齡、體重指數(body mass index,BMI)相匹配的健康中老年人的腰椎及股骨頸骨密度,收集相關生化、性激素及骨代謝指標,併對其與年齡、身高、體重、BMI、性激素水平及部分骨代謝指標進行多元逐步迴歸分析.結果 (1)PADAM組患者腰椎BMD與健康對照組差異無統計學意義(P＞0.05),但股骨頸各部位BMD均較健康對照組明顯降低[Neck:(0.831±0.136)g/cm2 vs(0.954±0.143)g/cm2,Ward's:(0.712±0.127)g/cm2 vs(0.811±0.149)g/cm2,Troch:(0.697±0.124)g/cm2 vs(0.764±0.131)g/cm2,P＜0.05)].(2)PADAM組及健康對照組骨量減少的髮生率分彆為48.9%、36%,骨質疏鬆的髮生率分彆為33.3%、20.8%.(3)PADAM患者腰椎BMD與BMI呈正相關;而股骨頸各部位BMD均與年齡呈負相關,與BMI、雄激素水平呈正相關(P＜0.05).結論 PADAM患者股骨頸各部位骨密度明顯降低.高齡、低體重指數和低雄激素水平為PADAM患者BMD降低的危險因素.
목적 탐토중노년남성웅격소부분결핍종합정(partial androgen deficiency in the aging male,PADAM)환자적골밀도(bone mineral density,BMD)특점급기영향인소.방법 채용쌍능X선골밀도의(dual energy X-ray absorptiometry,DEXA)측정186례중노년PADAM환자화125례년령、체중지수(body mass index,BMI)상필배적건강중노년인적요추급고골경골밀도,수집상관생화、성격소급골대사지표,병대기여년령、신고、체중、BMI、성격소수평급부분골대사지표진행다원축보회귀분석.결과 (1)PADAM조환자요추BMD여건강대조조차이무통계학의의(P＞0.05),단고골경각부위BMD균교건강대조조명현강저[Neck:(0.831±0.136)g/cm2 vs(0.954±0.143)g/cm2,Ward's:(0.712±0.127)g/cm2 vs(0.811±0.149)g/cm2,Troch:(0.697±0.124)g/cm2 vs(0.764±0.131)g/cm2,P＜0.05)].(2)PADAM조급건강대조조골량감소적발생솔분별위48.9%、36%,골질소송적발생솔분별위33.3%、20.8%.(3)PADAM환자요추BMD여BMI정정상관;이고골경각부위BMD균여년령정부상관,여BMI、웅격소수평정정상관(P＜0.05).결론 PADAM환자고골경각부위골밀도명현강저.고령、저체중지수화저웅격소수평위PADAM환자BMD강저적위험인소.
Objective To explore the characteristics and its influential factors of bone mineral density (BMD) changes in partial androgen deficiency in aging male patients.Methods 186 aging male patients with partial androgen deficiency and 125 healthy persons were selected, and their BMD in the first to fourth lumber spine and the proximal left femur was measured with the dual-energy X BMD measuring instrument.The biochemical and bone metabolic markers and sexual hormones were collected, and the relationship between changes of BMD in the patients with partial androgen deficiency, age, BMI, sexual hormones and bone metabolic markers were observed by multivariate stepwise regression analysis.Results There was no significant difference in BMD at the lumbar spine between two groups( P ＞ 0.05 ), but BMD in PADAM group was lower than control groups at the hip[Neck: (0.831 ±0.136) g/cm2 vs (0.954 ±0.143) g/cm2,War's: (0.712 ± 0.127 ) g/cm2 vs ( 0.811 ± 0.149 ) g/cm2,Troch: ( 0.697 ± 0.124 ) g/cm2 vs ( 0.764 ±0.131 )g/cm2, P ＜ 0.05 )].The incidence of PADAM and control group with osteopenia were 48.9% and 36%, and the osteoporosis was 33.3% and 20.8%, respectively.The bone mineral density was positively correlated to BMI at the first to fourth lumber spine and the proximal left femur in the patients with PADAM and negatively correlated to age and serum level of androgen.Conclusion BMD in PADAM group was significantly decreased, and age and low BMI and androgen deficiency wwere the risk factors of low BMD in PADAM patients.
