中华耳鼻咽喉头颈外科杂志
中華耳鼻嚥喉頭頸外科雜誌
중화이비인후두경외과잡지
CHINESE JOURNAL OF OTORHINOLARYNGOLOGY HEAD AND NECK SURGERY
2011年
10期
859-862
,共4页
李添应%陈德华%林志斌%徐睿
李添應%陳德華%林誌斌%徐睿
리첨응%진덕화%림지빈%서예
鼻炎,变应性,常年性%变应原%治疗结果%免疫疗法%投药,舌下
鼻炎,變應性,常年性%變應原%治療結果%免疫療法%投藥,舌下
비염,변응성,상년성%변응원%치료결과%면역요법%투약,설하
Rhinitis,allergic,perennial%Allergens%Treatment outcome%Immunotherapy%Administration,sublingual
目的 评价以粉尘螨滴剂变应原疫苗对变应性鼻炎( allergic rhinits,AR)患者进行舌下免疫治疗( sublingual immunotherapy,SLIT)的长期疗效.方法 206例年龄4～60岁AR患者,123例患者完成1年以上治疗,其中完成1、1.5、2年疗程的患者分别为61、41、21例.对3组患者治疗前后的鼻炎症状评分和用药评分进行分析比较.并且对用药1年和2年组患者停药1年后的症状进行比较分析,以SAS 6.12统计软件对数据进行统计学分析.结果 SLIT治疗1、1.5、2年后患者较治疗前出现明显症状改善,症状总分平均((x)±s,下同)由治疗前的(6.00±2.27)、(7.39±1.99)、(6.29±2.14)分降低为(2.95±1.82)、(3.28±2.58)、(2.48 ±1.99)分,差异有统计学意义(t值分别为8.19、10.29、5.97,P值均＜0.01).治疗后1、1.5、2年3个组无需用药患者的比例分别为68.9％、73.2％、80.9％,治疗前后差异有统计学意义(x2值分别为50.391、43.619、27.776,P值均＜0.01).SLIT治疗1、1.5、2年3组患者喷嚏、流涕、鼻塞、鼻痒症状改善相似,差异无统计学意义(F值分别为1.200、1.276、2.333,P值均＞0.05).2年组在SLIT结束后的1年观察中,无需用药患者百分比(76.2％)高于SLIT 1年组(61.3％),但差异无统计学意义(x2=1.263,P＞0.05).结论粉尘螨滴剂SLIT治疗1年即可较好地缓解AR症状,2年的疗程对于巩固疗效特别是降低对症药物的使用具有一定意义.
目的 評價以粉塵螨滴劑變應原疫苗對變應性鼻炎( allergic rhinits,AR)患者進行舌下免疫治療( sublingual immunotherapy,SLIT)的長期療效.方法 206例年齡4～60歲AR患者,123例患者完成1年以上治療,其中完成1、1.5、2年療程的患者分彆為61、41、21例.對3組患者治療前後的鼻炎癥狀評分和用藥評分進行分析比較.併且對用藥1年和2年組患者停藥1年後的癥狀進行比較分析,以SAS 6.12統計軟件對數據進行統計學分析.結果 SLIT治療1、1.5、2年後患者較治療前齣現明顯癥狀改善,癥狀總分平均((x)±s,下同)由治療前的(6.00±2.27)、(7.39±1.99)、(6.29±2.14)分降低為(2.95±1.82)、(3.28±2.58)、(2.48 ±1.99)分,差異有統計學意義(t值分彆為8.19、10.29、5.97,P值均＜0.01).治療後1、1.5、2年3箇組無需用藥患者的比例分彆為68.9％、73.2％、80.9％,治療前後差異有統計學意義(x2值分彆為50.391、43.619、27.776,P值均＜0.01).SLIT治療1、1.5、2年3組患者噴嚏、流涕、鼻塞、鼻癢癥狀改善相似,差異無統計學意義(F值分彆為1.200、1.276、2.333,P值均＞0.05).2年組在SLIT結束後的1年觀察中,無需用藥患者百分比(76.2％)高于SLIT 1年組(61.3％),但差異無統計學意義(x2=1.263,P＞0.05).結論粉塵螨滴劑SLIT治療1年即可較好地緩解AR癥狀,2年的療程對于鞏固療效特彆是降低對癥藥物的使用具有一定意義.
목적 평개이분진만적제변응원역묘대변응성비염( allergic rhinits,AR)환자진행설하면역치료( sublingual immunotherapy,SLIT)적장기료효.방법 206례년령4～60세AR환자,123례환자완성1년이상치료,기중완성1、1.5、2년료정적환자분별위61、41、21례.대3조환자치료전후적비염증상평분화용약평분진행분석비교.병차대용약1년화2년조환자정약1년후적증상진행비교분석,이SAS 6.12통계연건대수거진행통계학분석.결과 SLIT치료1、1.5、2년후환자교치료전출현명현증상개선,증상총분평균((x)±s,하동)유치료전적(6.00±2.27)、(7.39±1.99)、(6.29±2.14)분강저위(2.95±1.82)、(3.28±2.58)、(2.48 ±1.99)분,차이유통계학의의(t치분별위8.19、10.29、5.97,P치균＜0.01).치료후1、1.5、2년3개조무수용약환자적비례분별위68.9％、73.2％、80.9％,치료전후차이유통계학의의(x2치분별위50.391、43.619、27.776,P치균＜0.01).SLIT치료1、1.5、2년3조환자분체、류체、비새、비양증상개선상사,차이무통계학의의(F치분별위1.200、1.276、2.333,P치균＞0.05).2년조재SLIT결속후적1년관찰중,무수용약환자백분비(76.2％)고우SLIT 1년조(61.3％),단차이무통계학의의(x2=1.263,P＞0.05).결론분진만적제SLIT치료1년즉가교호지완해AR증상,2년적료정대우공고료효특별시강저대증약물적사용구유일정의의.
Objective To evaluate the efficacy of sublingual immunotherapy (SLIT) with dermatophagoides farianae drops in patients with allergic rhinitis (AR).Methods Two hundred and six patients with AR aged from 4 to 60 years were included in this study.Among them,123 patients completed more than one year treatment,the number of patients completed one year,one year and a half,two years were 61,41,21 cases.Rhinitis symptom scores and medication scores of the three groups before and after treatment were compared.And rhinitis symptom scores and medication scores of patients with one year drug withdrawal after one and two years treatment were aslo compared.Results Mter SLIT one year,one year and a half,two years treatment,the symptoms in these patients were significantly improved compared with before.The symptom scores ((x) ± s) were reduced from 6.00 ± 2.27,7.39 ± 1.99 and 6.29 ± 2.14 to 2.95 ± 1.82,3.28 ± 2.58,2.48 ± 1.99.The differences were statisticly significant (t value was 8.19,10.29,and 5.97,all P ＜0.01 ).The proportion of patients without drug treatment of the three group were 68.9％,73.2％ and 80.9％,there was statistical significance before and after treatment in every group ( value was 50.391,43.619,27.776,all P ＜ 0.01 ).Symptom improvement of sneezing,runny nose,nasal congestion,nasal itching were similar after one year,one year and a half,two years SLIT treatment,the differences were not statistically significant ( F values were 1.200,1.276 and 2.333,all P ＞ 0.05 ).The proportion of patients without drug treatment in the group which stopped medication one year after two year SLIT (76.2％) was higher than group stoped medication one year after one year SLIT (61.3％).There was no statistical significance ( x2 =1.263,P ＞ 0.05).Conclusion The dust mite drops can relieve symptoms after one year treatment,but the proposed two years treatment is important for the consolidation of improved sympotoms,especially for the effect of reducing the use of symptomatic medication.
