CAJ | 학술논문

目的探讨超声引导下建立肺动脉血栓栓塞所致犬急性肺动脉高压模型的可行性.方法模拟人体急性肺动脉血栓栓塞的病理生理过程,建立肺动脉血栓栓塞所致的犬急性肺动脉高压模型.超声引导下经股静脉穿刺,放置右心导管监测肺动脉压力,同时对侧股静脉推注自体血栓,以肺动脉收缩压超过30 mmHg为模型建立成功的标准.结果超声可以准确引导右心导管的放置.实验用犬27只,成功建立急性肺动脉高压模型24只,成功率88.9%.结论超声引导下建立肺动脉血栓栓塞所致犬急性肺动脉高压模型的方法具有良好的可行性和可重复性.
목적 탐토초성인도하건립폐동맥혈전전새소치견급성폐동맥고압모형적가행성.방법 모의인체급성폐동맥혈전전새적병리생리과정,건립폐동맥혈전전새소치적견급성폐동맥고압모형.초성인도하경고정맥천자,방치우심도관감측폐동맥압력,동시대측고정맥추주자체혈전,이폐동맥수축압초과30 mmHg위모형건립성공적표준.결과 초성가이준학인도우심도관적방치.실험용견27지,성공건립급성폐동맥고압모형24지,성공솔88.9%.결론 초성인도하건립폐동맥혈전전새소치견급성폐동맥고압모형적방법구유량호적가행성화가중복성.
Objective To establish a canine model with acute thrombo-embolic pulmonary hypertension monitored by echocardiography. Methods Simulated the pathophysiologic process of acute thrombo-embolic pulmonary hypertension in human, the canine model was developed. The femoral vein puncture and the right heart catheterization to monitor pulmonary artery pressure were operated guided by echocardiography, while the autologous blood clot was injected to the contralateral femoral vein. The criteria of model was the pulmonary artery systolic pressure was higher than 30 mmHg. Results Echocardiography can accurately guide the placement of right heart catheterization and ancillarily observe the pressure testing of pulmonary artery. Of twenty seven healthy experiment dogs, twenty four models with acute thromboembolic pulmonary hypertension were successfully developed. The successful rate was 88.9 %. Conclusions This canine model with acute thrombo-embolic pulmonary hypertension guided by echocardiography is easy to operate and its repeatability is good.