CAJ | 학술논문

疟疾是世界上主要的致死性感染性疾病之一,但是目前药物抗性虫株的出现、有效疫苗的缺乏,特别是对疟原虫生物学、疟疾病理机制以及宿主在疟原虫感染后的免疫应答等方面了解不足是控制疟疾的主要困难.大量研究发现,机体内的巨噬细胞迁移抑制因子(macrophage migration inhibitory factor,MIF)在包括疟疾在内的多种感染性疾病中发挥着重要作用,凶此受到研究者口益广泛的关注.近年来研究者们从疟原虫等寄生虫巾也先后鉴定出MIF分子,它们不仅在结构上具有高等牛物MIF分子的典型特征,而且还具有与之相似的功能.尽管其在感染过程巾的作用尚不清楚,但迄今为止多项研究表明,这些宿主MIF的同源分子具有调节宿主免疫系统的能力.该文综述了宿主MIF和寄生虫MIF在疟疾感染和病理机制中的作用的研究现状.
학질시세계상주요적치사성감염성질병지일,단시목전약물항성충주적출현、유효역묘적결핍,특별시대학원충생물학、학질병리궤제이급숙주재학원충감염후적면역응답등방면료해불족시공제학질적주요곤난.대량연구발현,궤체내적거서세포천이억제인자(macrophage migration inhibitory factor,MIF)재포괄학질재내적다충감염성질병중발휘착중요작용,흉차수도연구자구익엄범적관주.근년래연구자문종학원충등기생충건야선후감정출MIF분자,타문불부재결구상구유고등우물MIF분자적전형특정,이차환구유여지상사적공능.진관기재감염과정건적작용상불청초,단흘금위지다항연구표명,저사숙주MIF적동원분자구유조절숙주면역계통적능력.해문종술료숙주MIF화기생충MIF재학질감염화병리궤제중적작용적연구현상.
Malaria is one of the most deadly infeetious diseases in the wodd,however,the Control step is hampered by the occurrence of drug-resistant parasites,absence of effective vaccine,and the limited knowledge of parasite biology,malaria pathology and host immune response to parasite infection.Host derived macmphage migration inhibitory factor(MIF)is a critical mediator involving in host immune response against infectious diseases,including malaria.Recently,several Plasmodium species derived MIFs were identitled and proved to possess similar structure and biological activities with mammalian host MIF.Ahhough the role of Plasmodium MIF during infection is incompletely undemtood.the potential of it to modulate host immune responses was confirmed.Here.we reviewed the current research on the roles of both host MIF and parasite MIF in malaria infeetion and pathology.