CAJ | 학술논문

目的探讨放射性碘治疗Graves病导致早发甲状腺功能减退症(甲减)的可能因素.方法对260例行131I治疗的Graves病患者进行随访研究,将1年随访期内诊断为早发甲减者纳入早发甲减组,其余纳入对照组.采用病例对照研究的方法,对2组患者的性别、年龄、甲状腺估重、摄碘功能、服用放射性药物情况等进行对比研究,探讨导致早发甲减的可能因素.结果早发甲减组36例,对照组212例,失访12例.根据甲状腺质量进行分级处理,早发甲减组与对照组甲状腺质量间的差异无统计学意义(u=1.589,P>0.05).早发甲减组与对照组131I转换率间的差异存在统计学意义(0.66±0.19比0.79±0.21,t=2.712,P<0.01).早发甲减组与对照组每克甲状腺给予131I活度(100μCi比90μCi)间的差异存在统计学意义(u=2.144,P<0.05).结论转换率和每克甲状腺给予的131I活度是影响早发甲减发生的因素.
목적 탐토방사성전치료Graves병도치조발갑상선공능감퇴증(갑감)적가능인소.방법 대260례행131I치료적Graves병환자진행수방연구,장1년수방기내진단위조발갑감자납입조발갑감조,기여납입대조조.채용병례대조연구적방법,대2조환자적성별、년령、갑상선고중、섭전공능、복용방사성약물정황등진행대비연구,탐토도치조발갑감적가능인소.결과 조발갑감조36례,대조조212례,실방12례.근거갑상선질량진행분급처리,조발갑감조여대조조갑상선질량간적차이무통계학의의(u=1.589,P>0.05).조발갑감조여대조조131I전환솔간적차이존재통계학의의(0.66±0.19비0.79±0.21,t=2.712,P<0.01).조발갑감조여대조조매극갑상선급여131I활도(100μCi비90μCi)간적차이존재통계학의의(u=2.144,P<0.05).결론 전환솔화매극갑상선급여적131I활도시영향조발갑감발생적인소.
Objective To explore the factors of predicting outcome of Graves disease after 131I therapy.Methods Two hundred and sixty patients with Graves disease were given 131I therapy and then were followed up for a year.Thirty six patients of early hypothyroidism were therapy group.Using case-control study method,gender,age,goiter size,radioactive iodine uptake,dose of 131I therapy and desired dose per gram of thyroid were compared between the early hypothyroidism group and control group to explore the value factor in predeting early hypithyroidism.Results Goiter size of patients of early hypothyroidism Was similar(μ=1.59,P>0.05)when thyroid were divided into Ⅰ,Ⅱ and Ⅲ degree by thyroid size.131I turnover rate of early hypothyroidism(0.66±0.19,0.79±0.21) wsa significanly lower than that in controlgroup(t=2.712,P<0.05).Desired dose per gram of thyroid of early hypothyroidism group were significantly higher than dose of patients of control group(u=2.144,P<0.05).Conclusion 131 I turnover rate and desired dose per gram of thyroid are two effective prognostic markers of early hypothyroidism.