CAJ | 학술논문

目的了解甲型H1N1流感大流行期间流感住院病例抗病毒药物使用情况及存在的问题.方法选择苏州市3家市级医院.查看2009年6月至2010年3月甲型H1N1流感大流行期间住院治疗的甲型H1N1流感病例的病历资料,了解抗病毒药物的使用情况及有关信息.结果 98%(222/226)的甲型H1N1流感住院病例在住院期间使用过抗病毒药物,其中92%(205/222)使用过神经氨酸酶抑制剂--奥司他韦,但仅18%是在发病后2 d内开始用药.未发现医院对住院甲型H1N1流感病例使用金刚烷胺、金刚乙胺等抗病毒药物.对医生进行访谈发现,就诊延迟、医生误诊、等待实验室检测与结果反馈等因素影响奥司他韦的及时使用.结论在甲型H1N1流感大流行期间,苏州市3家市级医院绝大多数住院病例使用了奥司他韦,但药物使用及时性差.需要开发甲型H1N1流感病毒的快速检测技术,提高医生的诊断水平,以缩短病例诊断时间,提高用药的时效性,改善这类抗病毒药物的使用效果.
목적 료해갑형H1N1류감대류행기간류감주원병례항병독약물사용정황급존재적문제.방법 선택소주시3가시급의원.사간2009년6월지2010년3월갑형H1N1류감대류행기간주원치료적갑형H1N1류감병례적병력자료,료해항병독약물적사용정황급유관신식.결과 98%(222/226)적갑형H1N1류감주원병례재주원기간사용과항병독약물,기중92%(205/222)사용과신경안산매억제제--오사타위,단부18%시재발병후2 d내개시용약.미발현의원대주원갑형H1N1류감병례사용금강완알、금강을알등항병독약물.대의생진행방담발현,취진연지、의생오진、등대실험실검측여결과 반궤등인소영향오사타위적급시사용.결론 재갑형H1N1류감대류행기간,소주시3가시급의원절대다수주원병례사용료오사타위,단약물사용급시성차.수요개발갑형H1N1류감병독적쾌속검측기술,제고의생적진단수평,이축단병례진단시간,제고용약적시효성,개선저류항병독약물적사용효과.
Objective To explore the use of antiviral drugs in treating the hospitalized patients of novel influence A(H1N1)in Suzhou city during the 2009-2010 influenza pandemic,so as to make the proper use of antiviral drugs during influenza epidemics.Methods We selected 3municipal hospitals and reviewed the medieal records of hospimlized patients suffered from novel influence A(H1N1)during June 2009 to March 2010,to gather antiviral use and other related information.Results 98%(222/226)of the hospitalized patients received antiviral treatment.Among them,92%(205/222)were given the neuraminidase inhibitor oseitamivir.However,only 18% of the patients who received oseltamivir were given the treatment within 2 days after the onset of the illness.Amantadine and rimantadinc were not used for any of the hospitalized patients.Through interview on the physicians,we identified that delay in seeing care,misdiagnosis,delay in laboratory diagnosis were factors affecting the timely use of oseltamivir.Conclusion The majority of the hospitalized patients suffered from novel influence A(H1N1)in the three municipal hospitals received oseltamivir treatment.However,in most occasions the drug was not used timely.Techniques of rapid detection and diagnosis for novel influenza A(H1N1)virus should be developed,and the diagnostic capabilities of the physicians improved,to increase the effectiveness of these antiviral drugs.