中华老年医学杂志
中華老年醫學雜誌
중화노년의학잡지
Chinese Journal of Geriatrics
2011年
10期
833-835
,共3页
刘辉%常乃柏%裴蕾%宁尚勇%李江涛%邢宝利%许小东
劉輝%常迺柏%裴蕾%寧尚勇%李江濤%邢寶利%許小東
류휘%상내백%배뢰%저상용%리강도%형보리%허소동
白血病,髓性,急性%白血病,淋巴样%核型分析%危险性评估
白血病,髓性,急性%白血病,淋巴樣%覈型分析%危險性評估
백혈병,수성,급성%백혈병,림파양%핵형분석%위험성평고
Leukemia,myeloid,acute%Leukemia,lymphoid%Karyotyping%Risk assessment
目的 探讨急性白血病患者的染色体核型分布特征及不同年龄组患者染色体预后分层特征.方法 采用骨髓短期培养和G显带技术对215例急性白血病患者进行染色体核型分析.结果 215例患者中,有足够可供分析分裂相者202例,检出异常克隆149例(73.8％),各年龄组异常克隆检出率分别为,≤30岁组73.0％(27/37),31～59岁组74.4％(64/86),≥60岁组73.4％(58/79),各年龄组异常克隆检出率差异无统计学意义(P=0.982).在检出分裂相的171例急性髓性白血病(AML)患者中,预后良好核型41例(24.0％),预后中等核型80例(46.8％),预后不良核型50例(29.2％)；预后良好核型中以t(15；17)最多(占65.9％)；预后中等核型中以正常核型为主(占53.8％)；预后不良核型中以复杂异常为主(占84.0％).≤30岁组预后良好、中等及不良染色体核型所占百分比分别为50.0％、36.4％和13.6％;31～59岁组分别为24.3％、48.7％和27.0％；≥60组分别为16.0％、48.0％和36.0％.≤30岁组预后良好核型所占比例较其他两组高(分别为P=0.021和0.001),≥60岁组预后不良核型所占比例高于≤30岁组(P=0.046).29例急性淋巴细胞白血病(ALL)患者具有预后不良核型者10例.结论 急性白血病患者染色体核型分析可为预后分层提供重要依据,AML患者随着年龄增长预后不良核型比例逐渐增高.
目的 探討急性白血病患者的染色體覈型分佈特徵及不同年齡組患者染色體預後分層特徵.方法 採用骨髓短期培養和G顯帶技術對215例急性白血病患者進行染色體覈型分析.結果 215例患者中,有足夠可供分析分裂相者202例,檢齣異常剋隆149例(73.8％),各年齡組異常剋隆檢齣率分彆為,≤30歲組73.0％(27/37),31～59歲組74.4％(64/86),≥60歲組73.4％(58/79),各年齡組異常剋隆檢齣率差異無統計學意義(P=0.982).在檢齣分裂相的171例急性髓性白血病(AML)患者中,預後良好覈型41例(24.0％),預後中等覈型80例(46.8％),預後不良覈型50例(29.2％)；預後良好覈型中以t(15；17)最多(佔65.9％)；預後中等覈型中以正常覈型為主(佔53.8％)；預後不良覈型中以複雜異常為主(佔84.0％).≤30歲組預後良好、中等及不良染色體覈型所佔百分比分彆為50.0％、36.4％和13.6％;31～59歲組分彆為24.3％、48.7％和27.0％；≥60組分彆為16.0％、48.0％和36.0％.≤30歲組預後良好覈型所佔比例較其他兩組高(分彆為P=0.021和0.001),≥60歲組預後不良覈型所佔比例高于≤30歲組(P=0.046).29例急性淋巴細胞白血病(ALL)患者具有預後不良覈型者10例.結論 急性白血病患者染色體覈型分析可為預後分層提供重要依據,AML患者隨著年齡增長預後不良覈型比例逐漸增高.
목적 탐토급성백혈병환자적염색체핵형분포특정급불동년령조환자염색체예후분층특정.방법 채용골수단기배양화G현대기술대215례급성백혈병환자진행염색체핵형분석.결과 215례환자중,유족구가공분석분렬상자202례,검출이상극륭149례(73.8％),각년령조이상극륭검출솔분별위,≤30세조73.0％(27/37),31～59세조74.4％(64/86),≥60세조73.4％(58/79),각년령조이상극륭검출솔차이무통계학의의(P=0.982).재검출분렬상적171례급성수성백혈병(AML)환자중,예후량호핵형41례(24.0％),예후중등핵형80례(46.8％),예후불량핵형50례(29.2％)；예후량호핵형중이t(15；17)최다(점65.9％)；예후중등핵형중이정상핵형위주(점53.8％)；예후불량핵형중이복잡이상위주(점84.0％).≤30세조예후량호、중등급불량염색체핵형소점백분비분별위50.0％、36.4％화13.6％;31～59세조분별위24.3％、48.7％화27.0％；≥60조분별위16.0％、48.0％화36.0％.≤30세조예후량호핵형소점비례교기타량조고(분별위P=0.021화0.001),≥60세조예후불량핵형소점비례고우≤30세조(P=0.046).29례급성림파세포백혈병(ALL)환자구유예후불량핵형자10례.결론 급성백혈병환자염색체핵형분석가위예후분층제공중요의거,AML환자수착년령증장예후불량핵형비례축점증고.
Objective To explore the karyotype distribution in elderly patients with acute leukemia (AL) and compare the prognostic characteristics of karyotype by age grouping.Methods Chromosomal karyotypes were analyzed in 215 cases with AL using the short-term culture of bone marrow cells and G-banding technique.Results There were 202 cases with enough mitosis for analysis and 149 cases(73.8％)with abnormal clone in 215 patients with AL.The rates of abnormal clone were 73.0％ (27/37),74.4％(64/86) and 73.4％ (58/79) in patients aged ≤30,31-59 and ≥60 years,respectively,and no difference were found among age groups (P=0.982).Among 171 patients with acute myeloid leukemia (AML) with detected mitosis,there were 41 better-risk cases (24.0 ％) with most frequent aberration of t(15;17) accounting for 65.9 ％,80 intermediate-risk cases (46.8 ％ ) with principal of normal karyotype accounting for 53.8 ％,and 50 poor-risk cases (29.2 ％)with complex karyotype occupied by 84.0％.The karyotype percentage of better-risk,intermediaterisk and poor-risk were 50.0％,36.4％ and 13.6％ in patients aged ≤30 years,24.3％,48.7％ and 27.0％ in aged 31-59 years,and 16.0％,48.0％ and 36.0％ in aged ≥ 60 years,respectively.The rate of better-risk karyotype was higher in patients aged ≤30 years than the other two groups (P=0.021and P=0.001) and the ratio of poor-risk karyotype higher in patients aged ≥ 60 years than in patients aged ≤30 years (P=0.046).Among 29 patients with acute lymphoblastic leukemia (ALL),10 cases had poor-risk and 19 cases had intermediate-risk karyotype.Conclusions Karyotype analysis provides an important basis for risk assessment and the rate of poor-risk karyotype may increase with the ageing in patients with AML.
