CAJ | 학술논문

HIV的中和抗体可以与HIV病毒特异结合并且阻断病毒侵入细胞的抗体.HIV中和抗体的靶位是病毒的膜蛋白上那些与细胞受体结合和膜融合有关的区域,抗体的结合与相关蛋白的构象紧密相关,目前的相关研究为抗HIV药物和杀微生物剂的研制提供了理论基础.HIV具有逃逸中和抗体的能力.因此,为设计有效的疫苗,需要对抗原进行理性设计,以便更有效的诱导广谱中和抗体.概述HIV的侵入机制,中和抗体与侵入关键蛋白、靶点以及抗HIV疫苗研究的关系和进展.
HIV적중화항체가이여HIV병독특이결합병차조단병독침입세포적항체.HIV중화항체적파위시병독적막단백상나사여세포수체결합화막융합유관적구역,항체적결합여상관단백적구상긴밀상관,목전적상관연구위항HIV약물화살미생물제적연제제공료이론기출.HIV구유도일중화항체적능력.인차,위설계유효적역묘,수요대항원진행이성설계,이편경유효적유도엄보중화항체.개술HIV적침입궤제,중화항체여침입관건단백、파점이급항HIV역묘연구적관계화진전.
Neutralizing antibodies specific for HIV can bind to the virus and inhibit HIV entry into host cells.The targets of HIV-specific neutralizing antibodies are the sites associated with receptor binding or membrane fusion on the envelop proteins of HIV.Relevant studies have provided theoretical basis for developing anti-HIV medicines and microbicides.The neutralization is sensitive to the conformation of related proteins.On the other hand, HIV has a latent ability to escape from antibodies neutralization.Therefore, the rational design of antigen to induce broad-spectrum neutralizing antibodies is necessary for the development of successful vaccines.This paper introduces HIV invasion mechanism as well as the relationship of HIV neutralizing antibodies with entry-related crucial proteins,targets and anti-HIV vaccines.