CAJ | 학술논문

目的观察放射性~(131)I联合甲亢舒口服液治疗甲状腺功能亢进症(甲亢)的效果.方法 465例甲亢患者,随机分为对照组235例,治疗组230例.对照组采用~(131)I治疗,治疗组在对照组的基础上加服甲亢舒口服液,观察两组疗效及治疗前后血清T_3、T_4、FT_3、FT_4、TSH水平变化.结果治疗组治疗后12个月的治愈率74.7%(172/230),高于对照组的65.1%(153/235)(χ~2=3.94,P＜0.05);治疗组总有效率88.6%,高于对照组的80.4%(χ~2=3.90,P＜0.05);两组治疗后12个月与治疗前比较,血清T3、T4、FT3、FT4水平明显下降,TSH水平上升(t=2.745、2.778、2.845、2.812、2.833,均P＜0.05),且治疗组治疗12个月后T_4、FT_3、FT_4水平较对照组的下降更明显(t=2.145、2.178、2.245,均P＜0.05);治疗组血清抗甲状腺球蛋白抗体、抗甲状腺微粒体抗体转阴率均显著高于对照组(χ~2=3.98、3.88,均P＜0.05).结论甲亢舒口服液联合~(131)I治疗甲亢效果显著.
목적 관찰방사성~(131)I연합갑항서구복액치료갑상선공능항진증(갑항)적효과.방법 465례갑항환자,수궤분위대조조235례,치료조230례.대조조채용~(131)I치료,치료조재대조조적기출상가복갑항서구복액,관찰량조료효급치료전후혈청T_3、T_4、FT_3、FT_4、TSH수평변화.결과 치료조치료후12개월적치유솔74.7%(172/230),고우대조조적65.1%(153/235)(χ~2=3.94,P＜0.05);치료조총유효솔88.6%,고우대조조적80.4%(χ~2=3.90,P＜0.05);량조치료후12개월여치료전비교,혈청T3、T4、FT3、FT4수평명현하강,TSH수평상승(t=2.745、2.778、2.845、2.812、2.833,균P＜0.05),차치료조치료12개월후T_4、FT_3、FT_4수평교대조조적하강경명현(t=2.145、2.178、2.245,균P＜0.05);치료조혈청항갑상선구단백항체、항갑상선미립체항체전음솔균현저고우대조조(χ~2=3.98、3.88,균P＜0.05).결론 갑항서구복액연합~(131)I치료갑항효과현저.
Objective To observe the treatment efficacy in patients with hyperthyroidism by ~(131) radioactive iodine in conjunction with Jiakangshu oral solution.Methods 465 cases with hyperthyroidism were divided into control group(n=235)and treatment group(n=230).In the treatment group on the basis of ~(131) iodine therapy plus service Jiakangshu oral solution.The contents of T_3,T_4,FT_3,FT_4,TSH were observed before and after treatment.Results The cure rate 74.7% in treatment group after treatment 12-month was higher than 65.1%(χ~2=3.94,P＜0.05),total effective rate 88.6% was higher than 80.4%(χ~2=3.90,P＜0.05).The contents of T_3,T_4,FT_3,FT_4,TSH drop,but TSH levels increased in two groups after 12 months with those before treatment(t=2.745,2.778,2.845,2.812,2.833,all P＜0.05).The contents of T_3,T_4,FT_3,FT_4 in treatment group decreased significantly compared with the control group after treatment 12 months(t=2.145,2.178,2.245,all P＜0.05).The negative conversion rate of TGAb,TMAb in the treatment group were significantly higher than control group(χ~2=3.98,3.88,all P＜0.05).Conclusion The treatment effecs are obvious in patients with hyperthyroidism by 131 radioactive iodine in conjunction with JiaKangShu oral solution.