中国医师进修杂志
中國醫師進脩雜誌
중국의사진수잡지
CHINESE JOURNAL OF POSTGRADUATES OF MEDICINE
2011年
33期
18-20
,共3页
心力衰竭,充血性%利钠肽,脑%辛伐他汀%缬沙坦
心力衰竭,充血性%利鈉肽,腦%辛伐他汀%纈沙坦
심력쇠갈,충혈성%리납태,뇌%신벌타정%힐사탄
Heart failure,congestive%Natriuretic peptide,brain%Simvastatin%Valsartan
目的 观察辛伐他汀联合缬沙坦治疗慢性心力衰竭(CHF)患者的疗效及对脑钠尿肽(BNP)和心功能的影响.方法96例CHF患者按随机数字表法分为两组,对照组48例给予常规治疗,观察组48例在常规治疗的基础上给予辛伐他汀联合缬沙坦治疗,两组疗程均为6个月.比较两组的临床疗效及BNP和心功能的变化.结果治疗后观察组总有效率[85.4％(41/48)]高于对照组[ 70.8％(34/48)],但差异无统计学意义(P＞0.05).两组治疗前BNP、左室收缩末期内径(LVESD)、左室舒张末期内径(LVEDD)和左室射血分数(LVEF)比较差异无统计学意义(P＞0.05).治疗后两组BNP、LVESD、LVEDD明显下降,LVEF明显升高,差异均有统计学意义(P＜ 0.05).观察组治疗后BNP、LVESD、LVEDD低于同期对照组[(0.72±0.14) μg/L比(1.21±0.22) μg/L,(36.14±3.92) mm比(41.32±4.22) mm,(46.85 ±4.11) mm比(54.31±4.96) mm],LVEF高于同期对照组[(44.62±3.38)％比(41.28±2.25)％],差异均有统计学意义(P＜0.05).结论辛伐他汀联合缬沙坦治疗CHF患者,能够提高临床疗效,降低血清BNP,改善患者的心功能,值得临床推广应用.
目的 觀察辛伐他汀聯閤纈沙坦治療慢性心力衰竭(CHF)患者的療效及對腦鈉尿肽(BNP)和心功能的影響.方法96例CHF患者按隨機數字錶法分為兩組,對照組48例給予常規治療,觀察組48例在常規治療的基礎上給予辛伐他汀聯閤纈沙坦治療,兩組療程均為6箇月.比較兩組的臨床療效及BNP和心功能的變化.結果治療後觀察組總有效率[85.4％(41/48)]高于對照組[ 70.8％(34/48)],但差異無統計學意義(P＞0.05).兩組治療前BNP、左室收縮末期內徑(LVESD)、左室舒張末期內徑(LVEDD)和左室射血分數(LVEF)比較差異無統計學意義(P＞0.05).治療後兩組BNP、LVESD、LVEDD明顯下降,LVEF明顯升高,差異均有統計學意義(P＜ 0.05).觀察組治療後BNP、LVESD、LVEDD低于同期對照組[(0.72±0.14) μg/L比(1.21±0.22) μg/L,(36.14±3.92) mm比(41.32±4.22) mm,(46.85 ±4.11) mm比(54.31±4.96) mm],LVEF高于同期對照組[(44.62±3.38)％比(41.28±2.25)％],差異均有統計學意義(P＜0.05).結論辛伐他汀聯閤纈沙坦治療CHF患者,能夠提高臨床療效,降低血清BNP,改善患者的心功能,值得臨床推廣應用.
목적 관찰신벌타정연합힐사탄치료만성심력쇠갈(CHF)환자적료효급대뇌납뇨태(BNP)화심공능적영향.방법96례CHF환자안수궤수자표법분위량조,대조조48례급여상규치료,관찰조48례재상규치료적기출상급여신벌타정연합힐사탄치료,량조료정균위6개월.비교량조적림상료효급BNP화심공능적변화.결과치료후관찰조총유효솔[85.4％(41/48)]고우대조조[ 70.8％(34/48)],단차이무통계학의의(P＞0.05).량조치료전BNP、좌실수축말기내경(LVESD)、좌실서장말기내경(LVEDD)화좌실사혈분수(LVEF)비교차이무통계학의의(P＞0.05).치료후량조BNP、LVESD、LVEDD명현하강,LVEF명현승고,차이균유통계학의의(P＜ 0.05).관찰조치료후BNP、LVESD、LVEDD저우동기대조조[(0.72±0.14) μg/L비(1.21±0.22) μg/L,(36.14±3.92) mm비(41.32±4.22) mm,(46.85 ±4.11) mm비(54.31±4.96) mm],LVEF고우동기대조조[(44.62±3.38)％비(41.28±2.25)％],차이균유통계학의의(P＜0.05).결론신벌타정연합힐사탄치료CHF환자,능구제고림상료효,강저혈청BNP,개선환자적심공능,치득림상추엄응용.
Objective To observe the effect of simvastatin combined with valsartan in treatment of chronic heart failure(CHF) and its affection on brain natriuretic pepfde(BNP) and heart function.Methods Ninety-six cases of CHF patients were classified into two groups by random digits table,which control group of 48 cases were treated with normal therapy,and observation group of 48 cases were treated with simvastatin combined with valsartan at the base of normal therapy.The clinical effect,BNP and heart function between two groups were compared.Results The clinical effective rate in observation group and control group was 85.4％ (41/48) and 70.8％ (34/48) (P ＞ 0.05).The levels of BNP,left ventricular end-systolic dimension (LVESD),left ventricular end-diatolic dimension (LVEDD) and left ventricular ejection fraction (LVEF)after treatment were (0.72 ± 0.14) μ g/L,(36.14 ± 3.92) mm,(46.85 ± 4.11 )mm and (44.62 ± 3.38)％ in observation group,while ( 1.21 ± 0.22 ) μ g/L,(41.32 ± 4.22 ) mm,(54.31 ± 4.96 ) mm and (41.28 ± 2.25 )％in control group.After treatment,the levels of BNP,LVESD and LVEDD were significantly decreased,LVEF was significantly higher in both groups (P＜ 0.05).Moreover,the levels of BNP,LVESD and LVEDD in observation group were significantly lower than those in control group (P＜ 0.05),LVEF was significantly higher than that in control group (P＜ 0.05 ).Conclusion Simvastatin combined with valsartan in treatment of CHF can enhance the clinical effect,decrease BNP level and improve heart function,which can be applied in clinic.
