CAJ | 학술논문

对793例健康体检者行口服葡萄糖耐量试验(OGTT),根据受试者工作特征曲线确定糖负荷1h血糖升高切割点,分为OGTT 1 h血糖正常583例(NGTN组)、OGTT 1 h血糖升高127例(NGT1H组)、葡萄糖耐量减低83例(IGT组),比较各组间的代谢指标及稳态模型胰岛素抵抗指数(HOMA-IR)、胰岛β细胞功能指数(HOMA-β)和胰岛素生成指数(IGI).NGT1H组体重指数、腰围、甘油三酯、空腹血糖高于NGTN组,高密度脂蛋白胆固醇低于NGTN组；NGT1H组的HOMA-β(4.5±0.7)和IGI(2.1±0.7)水平低于NGTN组(4.8±0.7,2.7±0.9),HOMA-IR(1.2±0.6)高于NGTN组(0.5±0.6),NGT1 H组HOMA-β水平高于IGT组(4.4±0.6),差异有统计学意义(P＜0.05).提示OGTT 1 h血糖升高也是机体糖代谢受损的指标,存在胰岛素早时相分泌异常和胰岛素抵抗.
대793례건강체검자행구복포도당내량시험(OGTT),근거수시자공작특정곡선학정당부하1h혈당승고절할점,분위OGTT 1 h혈당정상583례(NGTN조)、OGTT 1 h혈당승고127례(NGT1H조)、포도당내량감저83례(IGT조),비교각조간적대사지표급은태모형이도소저항지수(HOMA-IR)、이도β세포공능지수(HOMA-β)화이도소생성지수(IGI).NGT1H조체중지수、요위、감유삼지、공복혈당고우NGTN조,고밀도지단백담고순저우NGTN조；NGT1H조적HOMA-β(4.5±0.7)화IGI(2.1±0.7)수평저우NGTN조(4.8±0.7,2.7±0.9),HOMA-IR(1.2±0.6)고우NGTN조(0.5±0.6),NGT1 H조HOMA-β수평고우IGT조(4.4±0.6),차이유통계학의의(P＜0.05).제시OGTT 1 h혈당승고야시궤체당대사수손적지표,존재이도소조시상분비이상화이도소저항.
Based on the results of oral glucose tolerance test( OGTT )and the levels of 1-h plasma glucose ( 1 hPG),793 subjects were classified into three groups:583 with NGTN ( normal 1 hPG in OGTT),127 with NGT1 H( higher 1 hPG in OGTT) and 83 with IGT( impaired glucose tolerance).NGT1H group had large waist circumference,higher body mass index,fasting plasma glucose( FPG),triglyceride,and lower high density lipoprotein-cholesterol than those of NGTN group.NGT1 H group had higher homeostasis model assessment insulin index ( 1.2 ± 0.6),lower homeostasis model assessment β3 ( HOMA-β ) (4.5 ± 0.7 ) and insulinogenic index (2.1 ±0.7) than those of NGTN group(0.5 ±0.6,4.8 ±0.7,2.7 ±0.9,respectively,all P ＜0.05 ).HOMA-β of NGT1 H group was higher than that of IGT group(4.5 ±0.7 vs.4.4 ±0.6,P ＜0.05 ).The results indicate that 1 hPG in OGTT may identify a condition of glucose metabolic abnormalities characterized by insulin resistance and reduced β-cell function.