CAJ | 학술논문

目的探讨美沙酮维持治疗(MMT)男性海洛因依赖患者和健康对照(HC)组之间工作记忆的差异.方法对42例2010年5至10月在淮南市精神病医院门诊就诊的MMT患者及2010年5至12月与其人口学资料相匹配的31名健康志愿者进行空间、语音及面孔工作记忆测试,比较两组正确率及反应时间的差异.结果在排除焦虑、抑郁情绪及尿吗啡测试阳性情况下,MMT组在语音工作记忆,正确率低于HC组(分别为83％±9％,89％±10％),差异有统计学意义[t(71)=-2.631,P=0.010]；而在空间工作记忆,面孔工作记忆,2组正确率差异无统计学意义(P＞0.05)；2组在进行三项工作记忆测试时,反应时差异均无统计学意义(均P ＞0.05)；研究同时还发现,MMT剂量高低组间比较及MMT时间长短组间比较,均未发现存在工作记忆及执行功能的差异.结论 MMT患者工作记忆损伤并不均衡,可能与患者脑区损伤不同有关.MMT时间和剂量对患者工作记忆及执行功能并无显著影响.
목적 탐토미사동유지치료(MMT)남성해락인의뢰환자화건강대조(HC)조지간공작기억적차이.방법 대42례2010년5지10월재회남시정신병의원문진취진적MMT환자급2010년5지12월여기인구학자료상필배적31명건강지원자진행공간、어음급면공공작기억측시,비교량조정학솔급반응시간적차이.결과 재배제초필、억욱정서급뇨마배측시양성정황하,MMT조재어음공작기억,정학솔저우HC조(분별위83％±9％,89％±10％),차이유통계학의의[t(71)=-2.631,P=0.010]；이재공간공작기억,면공공작기억,2조정학솔차이무통계학의의(P＞0.05)；2조재진행삼항공작기억측시시,반응시차이균무통계학의의(균P ＞0.05)；연구동시환발현,MMT제량고저조간비교급MMT시간장단조간비교,균미발현존재공작기억급집행공능적차이.결론 MMT환자공작기억손상병불균형,가능여환자뇌구손상불동유관.MMT시간화제량대환자공작기억급집행공능병무현저영향.
Objective To explore the differences of working memory task performance between male patients with heroin dependence in methadone maintenance treatment (MMT) and healthy controls (HC).Methods A total of 42 heroin-dependent patients at Huainan City Psychiatric Hospital from May 2011 to October 2011 were compared with 31 gender- and age-matched HCs on such working memory tests as visualspace,visual-verbal and visual-face.Then the accurate rate and reaction time of the above tasks were between two groups.Results The participants with anxiety or depression were excluded.All MMT subjects were required to have negative urine toxicology screening tests.The accurate rate of verbal working memory of the patients was worse than that of HCs (83％ ±9％ vs 89％ ± 10％ ).And the difference was significant between two groups ( t (71) =- 2.631,P =0.010).The accurate rate of visual-object and visual-spatial working memory showed no significant differences between two groups ( P ＞ 0.05 ).The differences in reaction time on these tasks showed no statistical significance between two groups ( P ＞ 0.05 ).In addition,the dose of methadone and the duration of MMT revealed no significant effects on the performance of working memory and executive functions.Conclusion The disproportion impairment of patients on space,verbal and face working memory is probably due to the differential heroin-mediated injuries of encephalic regions.Methadone has no effect on working memory and executive functions in the patients with a history of heroin use during maintenance treatment intervention.