CAJ | 학술논문

目的研究西红花酸对大鼠实验性动脉粥样硬化的影响.方法采用给予大剂量维生素D2(VD2)后饲喂高胆固醇饲料诱发大鼠实验性动脉粥样硬化模型,测定大鼠血清总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白(LDL-C)、高密度脂蛋白(HDL-C)、丙二醛(MDA)含量和超氧化物歧化酶(SOD)活性.取主动脉和肝脏做病理切片检查.结果高、低剂量的西红花酸能显著降低动脉粥样硬化大鼠血清TC、LDL-C和MDA含量;显著升高血清HDL-C含量、SOD活性和抗动脉粥样硬化指数(AAI).病理切片结果表明,西红花酸能明显减轻模型大鼠动脉粥样硬化性损伤.结论西红花酸具有显著的抗大鼠实验性动脉粥样硬化作用.
목적연구서홍화산대대서실험성동맥죽양경화적영향.방법채용급여대제량유생소D2(VD2)후사위고담고순사료유발대서실험성동맥죽양경화모형,측정대서혈청총담고순(TC)、감유삼지(TG)、저밀도지단백(LDL-C)、고밀도지단백(HDL-C)、병이철(MDA)함량화초양화물기화매(SOD)활성.취주동맥화간장주병리절편검사.결과고、저제량적서홍화산능현저강저동맥죽양경화대서혈청TC、LDL-C화MDA함량;현저승고혈청HDL-C함량、SOD활성화항동맥죽양경화지수(AAI).병리절편결과표명,서홍화산능명현감경모형대서동맥죽양경화성손상.결론서홍화산구유현저적항대서실험성동맥죽양경화작용.
Object To study the effect of crocetin (CCT) on experimental atherosclerotic formation in rats. Methods Atherosclerotic rat models were replicated by administration of excessive vitamin D2 (VD2) followed by feeding a high-cholesterol diet. The blood samples were assayed for the content of TC,TG, LDL-C, HDL-C, MDA level, and the activity of SOD in serum. The sections of aortia and liver were examined. Results High-and low-dosages of CCT were found significantly to reduce serum TC, LDL-C,and MDA level; and elevate serum HDL-C level, SOD activity, and antiatherosclerotic index (AAI) in atherosclerotic rats. The histopathological observation of aortic arch showed the alleviation of atherosclerotic damage by CCT. Conclusion CCT has obvious antiatherosclerotic effect in rats.