中国生化药物杂志
中國生化藥物雜誌
중국생화약물잡지
CHINESE JOURNAL OF BIOCHEMICAL PHARMACEUTICS
2010年
2期
111-113
,共3页
丹皮酚%缺血再灌注%肿瘤坏死因子α%白介素1β
丹皮酚%缺血再灌註%腫瘤壞死因子α%白介素1β
단피분%결혈재관주%종류배사인자α%백개소1β
paeonol%ischemia-reperfusion%TNF-α%IL-1β
目的 观察丹皮酚对局灶性脑缺血再灌注损伤后炎症因子TNF-α和IL-1β的作用,并探讨其作用机制.方法 采用线栓法建立大鼠大脑中动脉栓塞模型.缺血2 h,再灌注22 h后,测定缺血侧脑组织及血清中TNF-α和IL-1β的含量.结果 丹皮酚组大鼠脑组织及血清中TNF-α和IL-1β含量较模型组下降,尤以高剂量组降低最为明显.结论 丹皮酚对大鼠局灶性脑缺血再灌注损伤具有保护作用,其作用机制可能与抑制炎症因子生成有关.
目的 觀察丹皮酚對跼竈性腦缺血再灌註損傷後炎癥因子TNF-α和IL-1β的作用,併探討其作用機製.方法 採用線栓法建立大鼠大腦中動脈栓塞模型.缺血2 h,再灌註22 h後,測定缺血側腦組織及血清中TNF-α和IL-1β的含量.結果 丹皮酚組大鼠腦組織及血清中TNF-α和IL-1β含量較模型組下降,尤以高劑量組降低最為明顯.結論 丹皮酚對大鼠跼竈性腦缺血再灌註損傷具有保護作用,其作用機製可能與抑製炎癥因子生成有關.
목적 관찰단피분대국조성뇌결혈재관주손상후염증인자TNF-α화IL-1β적작용,병탐토기작용궤제.방법 채용선전법건립대서대뇌중동맥전새모형.결혈2 h,재관주22 h후,측정결혈측뇌조직급혈청중TNF-α화IL-1β적함량.결과 단피분조대서뇌조직급혈청중TNF-α화IL-1β함량교모형조하강,우이고제량조강저최위명현.결론 단피분대대서국조성뇌결혈재관주손상구유보호작용,기작용궤제가능여억제염증인자생성유관.
Purpose To observe the effect of paeonol on inflammatory factors after focal cerebral ischemiareperfusion injury in rats and its possible mechanism of paeonol.Methods Focal cerebral ischemic model was established by MCAO in rats.After 2 hours of cerebral ischemia and 22 hours of reperfusion,the expression of TNF-α and IL-1β in brain was determined by immunohistochemistry.The content of TNF-α and IL-1β in serum was measured by ELISA.Results Compared with model group,the levels of TNF-α and IL-1β in brain and serum in rats in the paeonol groups were obviously decreased.Conclusion Paeonol could relieve brain damage induced by focal cerebral ischemia-reperfusion,which may be related to inhibiting the production of inflammatory factors.
