CAJ | 학술논문

目的探讨二维应变技术联合负荷超声评价犬急性心肌缺血再灌注模型存活心肌的应用价值.方法 24只健康杂种犬,阻断其左冠状动脉前降支90 min后再灌注120 min.运用二维斑点追踪显像(speckle tracking imaging,SRI)分别检测静息状态、再灌注状态和小剂量多巴酚丁胺负荷状态下左室前壁、前间壁各节段收缩期峰值纵向应变(peak-systolic longitudinal strain,SLpeak)、径向应变(peak-systolic radial strain,SRpeak)、圆周应变(peak-systolic circumferential strain,SCpeak).以用氯化三苯基四氮唑(2,3,5-triphenyltetrazoliumchloride,TTC)和伊文思蓝(Evans blue,EB)染色结果为标准,将前壁、前间隔各节段分为存活节段组和非存活节段组.结果 (1)基础状态下,存活节段组和非存活节段组之间SLpeak、SRpeak、SCpeak无显著性差异(P＞0.05)；(2)再灌注后,存活组和非存活组SLpeak、SRpeak、SCpeak均降低,但两组比较无显著性差异(P＞0.05);(3)与负荷试验前比较,多巴酚丁胺负荷后存活节段组SLpeak、SRpeak、SCpeak显著性增加(P＜0.05),非存活节段组各指标无明显变化(P＞0.05)；存活节段组与非存活节段组比较有显著性差异(P＜0.05).结论小剂量多巴酚丁胺负荷超声联合二维应变可准确评价心肌存活性.
목적 탐토이유응변기술연합부하초성평개견급성심기결혈재관주모형존활심기적응용개치.방법 24지건강잡충견,조단기좌관상동맥전강지90 min후재관주120 min.운용이유반점추종현상(speckle tracking imaging,SRI)분별검측정식상태、재관주상태화소제량다파분정알부하상태하좌실전벽、전간벽각절단수축기봉치종향응변(peak-systolic longitudinal strain,SLpeak)、경향응변(peak-systolic radial strain,SRpeak)、원주응변(peak-systolic circumferential strain,SCpeak).이용록화삼분기사담서(2,3,5-triphenyltetrazoliumchloride,TTC)화이문사람(Evans blue,EB)염색결과위표준,장전벽、전간격각절단분위존활절단조화비존활절단조.결과 (1)기출상태하,존활절단조화비존활절단조지간SLpeak、SRpeak、SCpeak무현저성차이(P＞0.05)；(2)재관주후,존활조화비존활조SLpeak、SRpeak、SCpeak균강저,단량조비교무현저성차이(P＞0.05);(3)여부하시험전비교,다파분정알부하후존활절단조SLpeak、SRpeak、SCpeak현저성증가(P＜0.05),비존활절단조각지표무명현변화(P＞0.05)；존활절단조여비존활절단조비교유현저성차이(P＜0.05).결론 소제량다파분정알부하초성연합이유응변가준학평개심기존활성.