CAJ | 학술논문

特应性皮炎是一种慢性、复发性、炎症性皮肤病,临床表现为剧烈瘙痒,严重影响患者心身健康.近年来特应性皮炎发病率增加,然而其病因和发病机制尚未完全阐明,且无有效的控制方法.搔抓可能是重要的诱发和加重因素,可刺激角质形成细胞释放趋化因子及促炎症细胞因子而诱发瘙痒-搔抓循环,破坏皮肤屏障而易于发生微生物感染,导致自身抗原的释放.瘙痒-搔抓循环、微生物感染及自身抗原均在特应性皮炎的发病中起重要作用.通过外用保湿剂、戴棉手套、湿包疗法、心理干预及剪短指甲等方法可避免搔抓.
특응성피염시일충만성、복발성、염증성피부병,림상표현위극렬소양,엄중영향환자심신건강.근년래특응성피염발병솔증가,연이기병인화발병궤제상미완전천명,차무유효적공제방법.소조가능시중요적유발화가중인소,가자격각질형성세포석방추화인자급촉염증세포인자이유발소양-소조순배,파배피부병장이역우발생미생물감염,도치자신항원적석방.소양-소조순배、미생물감염급자신항원균재특응성피염적발병중기중요작용.통과외용보습제、대면수투、습포요법、심리간예급전단지갑등방법가피면소조.
Atopic dermatitis (AD),which is a chronic and relapsing inflammatory skin disease with a clinical manifestation of severe itching,seriously impacts the physical and mental health of patients.In recent years the incidence of AD has been increasing.However,both the etiology and pathology have not been clarified,and there is no effective method for its control.Scratching may play important roles in the induction and aggravation of AD by triggering the itch-scratch cycle via stimulating keratinocytes to release chemokines and pro-inflammatory cytokines,as well as by causing the release of autoantigens via destroying skin barrier followed by microbial infection.The itch-scratch cycle,microbial infection and autoantigens all play essential roles in tbe pathogenesis of AD.Scratching can be avoided by emollients,cotton gloves,wet wrap therapy,psychological intervention and cutting fingernails short.