中华风湿病学杂志
中華風濕病學雜誌
중화풍습병학잡지
CHINESE JOURNAL OF RHEUMATOLOGY
2010年
5期
305-307
,共3页
李艳梅%赵义%慈春增%栗占国
李豔梅%趙義%慈春增%慄佔國
리염매%조의%자춘증%률점국
红斑狼疮,系统性%酶联免疫吸附测定%抗缪勒管激素%抗卵巢细胞抗体
紅斑狼瘡,繫統性%酶聯免疫吸附測定%抗繆勒管激素%抗卵巢細胞抗體
홍반랑창,계통성%매련면역흡부측정%항무륵관격소%항란소세포항체
Lupus erythematosus,systemic%Enzyme-linked immunosorbent assay%Anti-Müllerian hormone%Anti-ovarian antibodies
目的 研究抗缪勒管激素(AMH)在初治的女性系统性红斑狼疮(SLE)患者中的水平变化情况,并分析AMH与抗卵巢细胞抗体(AOAB)的关系.方法 选取84例女性初治SLE患者血清及同年龄范围的健康女性血清90份,采用酶联免疫吸附试验(ELISA)法检测患者及健康人血清中AMH及AOAB水平.采用t检验统计分析.结果初治女性SLE患者血清中AMH平均水平[(3.2±1.5)ng/ml],明显高于健康对照组[(2.6±1.4),ng/ml],差异有统计学意义(P<0.05),且与患者皮疹、肾炎及疾病活动度有相关性.SLE患者和健康人血清中AMH水平随年龄增加均呈现先升高后降低的趋势,但SLE患者血清AMH水平达到高峰的年龄较健康对照组延后.另一方面,女性SLE患者AOAB阳性率显著高于健康人,且AOAB阳性的SLE患者血清AMH水平[(4.1±1.8)ng/ml]显著高于AOAB阴性者[(2.7±1.1)ng/ml,差异有统计学意义(P<0.01).结论 初治的女性SLE患者血清AMH水平高于同龄健康女性,而且AMH的升高与SLE患者皮疹和肾炎的发生、疾病活动度及AOAB的存在具有相关性.
目的 研究抗繆勒管激素(AMH)在初治的女性繫統性紅斑狼瘡(SLE)患者中的水平變化情況,併分析AMH與抗卵巢細胞抗體(AOAB)的關繫.方法 選取84例女性初治SLE患者血清及同年齡範圍的健康女性血清90份,採用酶聯免疫吸附試驗(ELISA)法檢測患者及健康人血清中AMH及AOAB水平.採用t檢驗統計分析.結果初治女性SLE患者血清中AMH平均水平[(3.2±1.5)ng/ml],明顯高于健康對照組[(2.6±1.4),ng/ml],差異有統計學意義(P<0.05),且與患者皮疹、腎炎及疾病活動度有相關性.SLE患者和健康人血清中AMH水平隨年齡增加均呈現先升高後降低的趨勢,但SLE患者血清AMH水平達到高峰的年齡較健康對照組延後.另一方麵,女性SLE患者AOAB暘性率顯著高于健康人,且AOAB暘性的SLE患者血清AMH水平[(4.1±1.8)ng/ml]顯著高于AOAB陰性者[(2.7±1.1)ng/ml,差異有統計學意義(P<0.01).結論 初治的女性SLE患者血清AMH水平高于同齡健康女性,而且AMH的升高與SLE患者皮疹和腎炎的髮生、疾病活動度及AOAB的存在具有相關性.
목적 연구항무륵관격소(AMH)재초치적녀성계통성홍반랑창(SLE)환자중적수평변화정황,병분석AMH여항란소세포항체(AOAB)적관계.방법 선취84례녀성초치SLE환자혈청급동년령범위적건강녀성혈청90빈,채용매련면역흡부시험(ELISA)법검측환자급건강인혈청중AMH급AOAB수평.채용t검험통계분석.결과초치녀성SLE환자혈청중AMH평균수평[(3.2±1.5)ng/ml],명현고우건강대조조[(2.6±1.4),ng/ml],차이유통계학의의(P<0.05),차여환자피진、신염급질병활동도유상관성.SLE환자화건강인혈청중AMH수평수년령증가균정현선승고후강저적추세,단SLE환자혈청AMH수평체도고봉적년령교건강대조조연후.령일방면,녀성SLE환자AOAB양성솔현저고우건강인,차AOAB양성적SLE환자혈청AMH수평[(4.1±1.8)ng/ml]현저고우AOAB음성자[(2.7±1.1)ng/ml,차이유통계학의의(P<0.01).결론 초치적녀성SLE환자혈청AMH수평고우동령건강녀성,이차AMH적승고여SLE환자피진화신염적발생、질병활동도급AOAB적존재구유상관성.
Objective To evaluate the serum anti-Müllerian hormone(AMH)level in female patients with systemic lupus erythematosus (SLE),and to explore the association between AMH and anti-ovarian antibody(AOAB).Methods Serum levels of AMH and AOAB were measured with ELISA in 84 female SLE patients and 90 age-matched healthy women.The patients were not treated with steroids or immunosuppressive agents before their blood samples were collected.Clinical and laboratory data of the SLE patients were also analyzed by two independent samples t-test.Results The mean serum AMH level of 84 female SLE patients was (3.2±1.5)ng/ml,which was higher than that of 90 age-matched healthy women[(2.6±1.4)ng/ml,P<0.05].Moreover,the serum AMH level was closely associated with rash,lupus nephritis,and disease activity in the 84 SLE patients.The results showed that the serum AMH levels increased first,then decreased with aging,both in SLE patients and healthy women,but the appearance of peak serum AMH level in SLE patients was delayed.The frequency of AOAB wilts higher than that in healthy women.Interestingly,the mean serum AMH level of the AOAB-positive group[(4.1±1.8)ng/ml]was higher than that of the AOAB-negative group [(2.7±1.1)ng/ml,P<0.01].Conclusion The mean level of serum AMH in female SLE patients is higher than that in age-matched healthy women,and its high level in SLE patients is closely associated with rash,lupus nephritis,disease activity and serum AOAB level.
