中国医师杂志
中國醫師雜誌
중국의사잡지
JOURNAL OF CHINESE PHYSICIAN
2011年
10期
1327-1329
,共3页
胆囊肿瘤/代谢%STAT3转录因子/代谢%微管相关蛋白质类/代谢
膽囊腫瘤/代謝%STAT3轉錄因子/代謝%微管相關蛋白質類/代謝
담낭종류/대사%STAT3전록인자/대사%미관상관단백질류/대사
Gallbladder neoplasms/ME%STAT3 transcription factor/ME%Microtubule-associated proteins/ME
目的 探讨胆囊癌中p-STAT3和survivin蛋白表达及其在胆囊癌发生、发展中的作用.方法 采用免疫组织化学SP法检测45例胆囊癌组织、20例慢性胆囊炎组织中p-STAT3及survivin蛋白的表达,并分析其与临床病理特征、预后的关系.结果 本组45例胆囊癌组织中p-STAT3和survivin蛋白阳性率分别为55.6%( 25/45)、64.4%( 29/45),明显高于慢性胆囊炎组织5.0%(1/20)、10%(2/20)(P<0.01).在胆囊癌组织中p-STAT3的表达与survivin表达呈正相关(r=0.830,P<0.01).p-STAT3和survivin蛋白的表达与胆囊癌病理组织分级、Nevin分期、有无淋巴结转移和3年生存率有关(P <0.01,P<0.05).结论 p-STAT3、survivin参与了胆囊癌的发生、发展,可能作为判断胆囊癌转移、预后的临床指标.
目的 探討膽囊癌中p-STAT3和survivin蛋白錶達及其在膽囊癌髮生、髮展中的作用.方法 採用免疫組織化學SP法檢測45例膽囊癌組織、20例慢性膽囊炎組織中p-STAT3及survivin蛋白的錶達,併分析其與臨床病理特徵、預後的關繫.結果 本組45例膽囊癌組織中p-STAT3和survivin蛋白暘性率分彆為55.6%( 25/45)、64.4%( 29/45),明顯高于慢性膽囊炎組織5.0%(1/20)、10%(2/20)(P<0.01).在膽囊癌組織中p-STAT3的錶達與survivin錶達呈正相關(r=0.830,P<0.01).p-STAT3和survivin蛋白的錶達與膽囊癌病理組織分級、Nevin分期、有無淋巴結轉移和3年生存率有關(P <0.01,P<0.05).結論 p-STAT3、survivin參與瞭膽囊癌的髮生、髮展,可能作為判斷膽囊癌轉移、預後的臨床指標.
목적 탐토담낭암중p-STAT3화survivin단백표체급기재담낭암발생、발전중적작용.방법 채용면역조직화학SP법검측45례담낭암조직、20례만성담낭염조직중p-STAT3급survivin단백적표체,병분석기여림상병리특정、예후적관계.결과 본조45례담낭암조직중p-STAT3화survivin단백양성솔분별위55.6%( 25/45)、64.4%( 29/45),명현고우만성담낭염조직5.0%(1/20)、10%(2/20)(P<0.01).재담낭암조직중p-STAT3적표체여survivin표체정정상관(r=0.830,P<0.01).p-STAT3화survivin단백적표체여담낭암병리조직분급、Nevin분기、유무림파결전이화3년생존솔유관(P <0.01,P<0.05).결론 p-STAT3、survivin삼여료담낭암적발생、발전,가능작위판단담낭암전이、예후적림상지표.
Objective To detect the expression of p-STAT3 and survivin in primary gallbladder carcinoma (PGC) and explore its significance for the genesis and development of PGC.Methods The expression of p-STAT3 and survivin were determined with immunohistochemistry in samples from 45 PGC tissues and 20 chronic cholecystitis.The relationship between the expression of these proteins and various clinicopathological factors was evaluated.Results The expression rate of p-STAT3 and survivin in 45 PGC tissues was 55.6% ( 25/45 ) and 64.4% ( 25/45 ),respectively,which was significantly higher than those in 20chronic cholecystitis tissues 5.0% ( 1/20),10% ( 2/20 ) ( P < 0.01 ).pSTAT3 expression was correlated with survivin ( r =0.830,P <0.01 ).p-STAT3 and survivin protein expression were significantly associated with histopathological grading,lymph node metastatis,nevin staging and 3-year survival rate.Conclusions p-STAT3 and survivin might play a vital role in the development of PGC.The expression of p-STAT3 or survivin was an independent prognostic factor in PGC.