中华心血管病杂志
中華心血管病雜誌
중화심혈관병잡지
Chinese Journal of Cardiology
2012年
5期
382-385
,共4页
杨静%徐东%沈珠军%王崇慧%张抒扬%范中杰%金晓峰%曾勇%刘震宇%谢洪智%方全
楊靜%徐東%瀋珠軍%王崇慧%張抒颺%範中傑%金曉峰%曾勇%劉震宇%謝洪智%方全
양정%서동%침주군%왕숭혜%장서양%범중걸%금효봉%증용%류진우%사홍지%방전
红斑狼疮,系统性%冠状动脉疾病%冠状动脉造影术%抗磷脂综合征
紅斑狼瘡,繫統性%冠狀動脈疾病%冠狀動脈造影術%抗燐脂綜閤徵
홍반랑창,계통성%관상동맥질병%관상동맥조영술%항린지종합정
Lupus erythematosus,systemic%Coronary artery disease%Coronary angiography%Antiphospholipid syndrome
目的 阐述系统性红斑狼疮(SLE)合并冠状动脉疾病患者的临床特征和冠状动脉表现.方法 1999年1月至2009年10月在北京协和医院住院的年龄≥18岁的SLE患者共2877例,其中男性363例,女性2514例.对在SLE发病之后并发冠状动脉疾病的33例患者的临床资料及其中20例患者的冠状动脉病变特征进行回顾性分析.结果 SLE患者出现冠状动脉疾病年龄23～74岁,平均(50.7±12.8)岁,SLE和冠状动脉疾病发病间隔平均(8.0±7.1)年.男性SLE患者冠状动脉疾病发生率有高于女性的趋势[2.48％ (9/363)比0.95％ (24/2514),P=0.022].继发抗磷脂综合征(APS)患者冠状动脉疾病发生率明显增加[5.76％(8/139)比0.91％(25/2738),P＜0.001].24例患者冠状动脉疾病的临床表现为心肌梗死；冠状动脉造影可见血管闭塞、狭窄、瘤样扩张和急性血栓形成,75.0％(15/20)的病例为多支病变.结论 男性和继发抗磷脂综合征SLE患者冠状动脉疾病发生率高；SLE合并冠状动脉疾病者冠状动脉病变广泛,常常发生心肌梗死.
目的 闡述繫統性紅斑狼瘡(SLE)閤併冠狀動脈疾病患者的臨床特徵和冠狀動脈錶現.方法 1999年1月至2009年10月在北京協和醫院住院的年齡≥18歲的SLE患者共2877例,其中男性363例,女性2514例.對在SLE髮病之後併髮冠狀動脈疾病的33例患者的臨床資料及其中20例患者的冠狀動脈病變特徵進行迴顧性分析.結果 SLE患者齣現冠狀動脈疾病年齡23～74歲,平均(50.7±12.8)歲,SLE和冠狀動脈疾病髮病間隔平均(8.0±7.1)年.男性SLE患者冠狀動脈疾病髮生率有高于女性的趨勢[2.48％ (9/363)比0.95％ (24/2514),P=0.022].繼髮抗燐脂綜閤徵(APS)患者冠狀動脈疾病髮生率明顯增加[5.76％(8/139)比0.91％(25/2738),P＜0.001].24例患者冠狀動脈疾病的臨床錶現為心肌梗死；冠狀動脈造影可見血管閉塞、狹窄、瘤樣擴張和急性血栓形成,75.0％(15/20)的病例為多支病變.結論 男性和繼髮抗燐脂綜閤徵SLE患者冠狀動脈疾病髮生率高；SLE閤併冠狀動脈疾病者冠狀動脈病變廣汎,常常髮生心肌梗死.
목적 천술계통성홍반랑창(SLE)합병관상동맥질병환자적림상특정화관상동맥표현.방법 1999년1월지2009년10월재북경협화의원주원적년령≥18세적SLE환자공2877례,기중남성363례,녀성2514례.대재SLE발병지후병발관상동맥질병적33례환자적림상자료급기중20례환자적관상동맥병변특정진행회고성분석.결과 SLE환자출현관상동맥질병년령23～74세,평균(50.7±12.8)세,SLE화관상동맥질병발병간격평균(8.0±7.1)년.남성SLE환자관상동맥질병발생솔유고우녀성적추세[2.48％ (9/363)비0.95％ (24/2514),P=0.022].계발항린지종합정(APS)환자관상동맥질병발생솔명현증가[5.76％(8/139)비0.91％(25/2738),P＜0.001].24례환자관상동맥질병적림상표현위심기경사；관상동맥조영가견혈관폐새、협착、류양확장화급성혈전형성,75.0％(15/20)적병례위다지병변.결론 남성화계발항린지종합정SLE환자관상동맥질병발생솔고；SLE합병관상동맥질병자관상동맥병변엄범,상상발생심기경사.
Objectives To observe the clinical and coronary features of patients with systemic lupus erythematosus (SLE) and coronary artery disease (CAD).Methods Among 2877 SLE inpatients ( age ≥ 18 years,male 363,female 2514) admitted in the Peking Union Medical College Hospital between January 1999 to October 2009,33 patients [ mean age (50.7 ± 12.8) years] were diagnosed with CAD and coronary angiogram was available in 20 out of these 33 patients.Clinical and coronary features of these patients were retrospectively reviewed.Results The incidence of CAD was significantly higher in male SLE patients than in female patients [2.48％ (9/363) vs.0.95％ (24/2514),P =0.022].Patients with secondary antiphospholipid syndrome were more likely to suffer from CAD [5.76％ (8/139) vs.0.91％ (25/2738),P＜0.001 ].Myocardial infarction was the major form of CAD (24/33). Coronary artery angiographic changes included coronary stenosis and occlusions,coronary aneurysms and acute thrombosis and multivessel lesions was found in 75.0％ (15/20) patients with SLE and CAD.Conclusions Male SLE patients and patients with secondary antiphospholipid syndrome are at higher risk for CAD.Myocardial infarction and multi-vessel lesions are common in SLE patients with CAD.
