CAJ | 학술논문

细胞凋亡是一种生理性细胞死亡机制,它是由基因控制的细胞自主的有序的死亡过程.细胞自噬是一种自我消化过程,通过包裹细胞内成分,再与溶酶体溶合,进而降解细胞成分.细胞自噬与凋亡之间存在复杂联系,在一定条件下自噬是细胞对应激适应性反应从而避免发生死亡,而在其他环境中,自噬是细胞死亡的替代途径.Bel-2家族成员在细胞凋亡与自噬过程中发挥着交叉性作用.本综述主要总结Bcl-2家族成员在细胞自噬中研究进展.
세포조망시일충생이성세포사망궤제,타시유기인공제적세포자주적유서적사망과정.세포자서시일충자아소화과정,통과포과세포내성분,재여용매체용합,진이강해세포성분.세포자서여조망지간존재복잡련계,재일정조건하자서시세포대응격괄응성반응종이피면발생사망,이재기타배경중,자서시세포사망적체대도경.Bel-2가족성원재세포조망여자서과정중발휘착교차성작용.본종술주요총결Bcl-2가족성원재세포자서중연구진전.
Apoptosis, a mechanism of cell physiological death, is a kind of autonomic and order death process sequence-controlled by gene. Cell Autophngy is a kind process of serf-degrade, by enwraping cytosol and organelles, fusing with the lysosome, finally degrading lumen. There is complex relation between apop-tosis and autophngy. Autophngy can protect cells against death during stress, but it can also mediate cellular demise, depending on the specific circumstances. Bcl-2 family plays an intercross role apeptosis and autoph-ngy. This review focuses on the current research progress of the role of Bcl-2 family in cell autophagy.