CAJ | 학술논문

目的探讨n-3不饱和脂肪酸(PUFA)对改善抑郁的作用.方法 39例自杀未遂的抑郁症患者在接受标准抗抑郁药物治疗过程中服用PUFA及安慰剂3个月,应用汉密尔顿抑郁量表及贝克抑郁自评问卷在干预前,干预1.5个月及干预3个月时进行评估.结果 1.干预前和干预后n-3PUFA组和安慰剂组之间汉密顿抑郁量表(HRSD)得分[(23.52±6.92)分,(21.56±8.71)分;(14.62±9.28)分,(12.00±8.54)分]上的均差异无显著性(P>0.05);干预前和干预后n-3PUFA组和安慰剂组之间BDI的得分上的均差异无显著性(P>0.05).2.2组红细胞膜中二十碳五烯酸水平,二十二碳六烯酸水平及n-6/n-3水平干预1.5个月和干预3个月时均差异具有显著性(P<0.05).结论 n-3不饱和脂肪酸无辅助治疗抑郁症的作用.
목적 탐토n-3불포화지방산(PUFA)대개선억욱적작용.방법 39례자살미수적억욱증환자재접수표준항억욱약물치료과정중복용PUFA급안위제3개월,응용한밀이돈억욱량표급패극억욱자평문권재간예전,간예1.5개월급간예3개월시진행평고.결과 1.간예전화간예후n-3PUFA조화안위제조지간한밀돈억욱량표(HRSD)득분[(23.52±6.92)분,(21.56±8.71)분;(14.62±9.28)분,(12.00±8.54)분]상적균차이무현저성(P>0.05);간예전화간예후n-3PUFA조화안위제조지간BDI적득분상적균차이무현저성(P>0.05).2.2조홍세포막중이십탄오희산수평,이십이탄륙희산수평급n-6/n-3수평간예1.5개월화간예3개월시균차이구유현저성(P<0.05).결론 n-3불포화지방산무보조치료억욱증적작용.
Objective To determine the effect of adding n-3 polyunsaturated fatty acids in attempted suicides who were depression.Methods A randomized double-blind placebo-controlled 3 months trial comparing n-3 polyunsaturated fatty acids versus placebo was conducted on 39 attempted suicides who were depression.Mood was assessed at baseline and then 1.5 and 3 months using the Hamilton Rating Scale for Depression(HRSD)and the Beck Depression Inventory(BDI).Results 1.There were no significant differences between n-3 PUFA intervention group and control group on scores of HRSD at baseline and after 3 months intervention(23.52±6.92,21.56±8.71;14.62±9.28,12.00±8.54)(P>0.05).There were no significant differences between n-3 PUFA intervention group and control group on scores of BDI at baseline and after 3 months intervention(P＞0.05).2.There were significant differences between n-3 PUFA intervention group and control group on EPA,DHA and n-6/n-3 at 2 points of time(P<0.05).Conclusion n-3 polyunsaturated fatty acids were not effective as an add-on therapy for depression.