CAJ | 학술논문

目的：探讨白细胞介素-10(IL-10)、白细胞介素-12(IL-12)对动脉粥样硬化(AS)形成和发展的影响。方法：分别对18例急性心肌梗死(AMI)患者于发病当天及第3，5，7，10，14天；14例不稳定型心绞痛(UAP)患者及10例健康对照者测定血清IL-10、IL-12水平。结果：①UAP患者IL-10、IL-12水平显著高于对照组。②AMI患者血清IL-10于发病当天至第5天显著高于其他两组，并于第3天达高峰。IL-12于发作当天及第10～14天显著高于对照组。③AMI死亡组IL-10水平明显高于生存组，而IL-12无显著性差异。结论：提示急性冠状动脉事件患者IL-10、IL-12升高，二者可能参与了AS的形成和发展，并可作为急性期预测指标。
목적：탐토백세포개소-10(IL-10)、백세포개소-12(IL-12)대동맥죽양경화(AS)형성화발전적영향。방법：분별대18례급성심기경사(AMI)환자우발병당천급제3，5，7，10，14천；14례불은정형심교통(UAP)환자급10례건강대조자측정혈청IL-10、IL-12수평。결과：①UAP환자IL-10、IL-12수평현저고우대조조。②AMI환자혈청IL-10우발병당천지제5천현저고우기타량조，병우제3천체고봉。IL-12우발작당천급제10～14천현저고우대조조。③AMI사망조IL-10수평명현고우생존조，이IL-12무현저성차이。결론：제시급성관상동맥사건환자IL-10、IL-12승고，이자가능삼여료AS적형성화발전，병가작위급성기예측지표。
Objective:To determine the levels of IL-10 and IL-12 in sera frompatients with acute coronary artery syndrome (ACS), and to investigate the relationship between these levels and the degree of AS. Method:IL-10 and IL-12 levels in sera were assayed by ELISA from 18 patients with acute myocardial infarction (AMI) and from 14 patients with unstable angina pectoris(UAP) and 10 normal controls. Result:The levels of IL- 10 and IL-12 in sera from the UAP group were much higher than those of controls. IL-10 levels in sera from the AMI group on the first to fifth days after onset were higher than those of the other two groups, and the IL-10 level on the seventh days after onset was higher than those of controls, and reached its maximum on the third days after onset. However, the level of IL-12 in sera was significantly higher than that of controls on the onset day and the tenth to fourteenth days. Among AMI patients, only the peak IL-12 level on the fourteenth day was significantly higher than that of UAP patients. On the third day after onset, IL-10 level in sera of dead patients with AMI was higher than that of survivors. Conclusion:Compared to normal controls, patients with acute coronary artery syndrome have higher levels of IL-10 and IL-12, which indicate the potential roles played by IL-10/IL-12 in the process of AS. The cross-regulatory roles of IL-10 and IL-12 may contribute to the pathogenesis of AS, specifically, these factors may act as indicators of AS severity and prognosis of AMI.