中国抗生素杂志
中國抗生素雜誌
중국항생소잡지
CHINESE JOURNAL OF ANTIBIOTICS
2010年
1期
33-36
,共4页
魏文珑%梁莉毓%邢俊德%常宏宏%李兴
魏文瓏%樑莉毓%邢俊德%常宏宏%李興
위문롱%량리육%형준덕%상굉굉%리흥
GCLE%酯化%氧化%开环%取代%氯化%闭环
GCLE%酯化%氧化%開環%取代%氯化%閉環
GCLE%지화%양화%개배%취대%록화%폐배
GCLE%Esterifation%Oxidation%Ring opening%Substitution%Chlorination%Closed loop
以青霉素G钾盐为原料,经酯化、氧化、开环、取代、氯化、闭环反应合成头孢类中间体GCLE,目标产物及各中间体经熔点、IR、~1H-NMR、HPLC等方法进行分析,反应总收率可达30.2%.
以青黴素G鉀鹽為原料,經酯化、氧化、開環、取代、氯化、閉環反應閤成頭孢類中間體GCLE,目標產物及各中間體經鎔點、IR、~1H-NMR、HPLC等方法進行分析,反應總收率可達30.2%.
이청매소G갑염위원료,경지화、양화、개배、취대、록화、폐배반응합성두포류중간체GCLE,목표산물급각중간체경용점、IR、~1H-NMR、HPLC등방법진행분석,반응총수솔가체30.2%.
Starting from Penicillin G potassium salt, cephalosporin intermediate GCLE was synthesized in an overall yield of 30.2%.The target product and other intermediates were characterized by melting point, IR, ~1H-NMR, HPLC together with other methods.
