中国男科学杂志
中國男科學雜誌
중국남과학잡지
CHINESE JOURNAL OF ANDROLOGY
2010年
2期
9-11
,共3页
李亚南%刘坚%肖丽萍%陈晓清%张晓峰%余新沛%刘岗%杨明常%宋骤%毕向军
李亞南%劉堅%肖麗萍%陳曉清%張曉峰%餘新沛%劉崗%楊明常%宋驟%畢嚮軍
리아남%류견%초려평%진효청%장효봉%여신패%류강%양명상%송취%필향군
前列腺增生%维生素D%血清%生物化学%小鼠
前列腺增生%維生素D%血清%生物化學%小鼠
전렬선증생%유생소D%혈청%생물화학%소서
prostatic hyperplasia%vitamin D: serum%biochemistry%mice
目的 通过观察维生素D对前列腺增生小鼠动物模型血清生化指标的影响,探讨不同剂量维生素D对前列腺增生动物模型的血清生化指标影响.方法 应用丙酸睾酮肌肉注射制造小鼠前列腺增生模型.随机分组,采用不同剂量的维生素D剂喂养4周后,检测小鼠血清电解质、肝肾功能、血脂等指标.结果 应用0.2、1.0和5.0 μg/kg·d~(-1)的各组小鼠检测结果显示:应用维生素D对前列腺增生小鼠的肾功能无明显负面影响;但是大剂量维生素D对血清谷草转氨酶(AST)有升高作用;中、大剂量维生素D可以升高血清钙离子浓度,对镁、磷无明显影响.结论 中、小剂量维生素D对小鼠前列腺增生模型的肝肾功能、电解质未发现明显负面影响,大剂量维生素D可能对血清钙离子浓度、AST有一定影响.
目的 通過觀察維生素D對前列腺增生小鼠動物模型血清生化指標的影響,探討不同劑量維生素D對前列腺增生動物模型的血清生化指標影響.方法 應用丙痠睪酮肌肉註射製造小鼠前列腺增生模型.隨機分組,採用不同劑量的維生素D劑餵養4週後,檢測小鼠血清電解質、肝腎功能、血脂等指標.結果 應用0.2、1.0和5.0 μg/kg·d~(-1)的各組小鼠檢測結果顯示:應用維生素D對前列腺增生小鼠的腎功能無明顯負麵影響;但是大劑量維生素D對血清穀草轉氨酶(AST)有升高作用;中、大劑量維生素D可以升高血清鈣離子濃度,對鎂、燐無明顯影響.結論 中、小劑量維生素D對小鼠前列腺增生模型的肝腎功能、電解質未髮現明顯負麵影響,大劑量維生素D可能對血清鈣離子濃度、AST有一定影響.
목적 통과관찰유생소D대전렬선증생소서동물모형혈청생화지표적영향,탐토불동제량유생소D대전렬선증생동물모형적혈청생화지표영향.방법 응용병산고동기육주사제조소서전렬선증생모형.수궤분조,채용불동제량적유생소D제위양4주후,검측소서혈청전해질、간신공능、혈지등지표.결과 응용0.2、1.0화5.0 μg/kg·d~(-1)적각조소서검측결과현시:응용유생소D대전렬선증생소서적신공능무명현부면영향;단시대제량유생소D대혈청곡초전안매(AST)유승고작용;중、대제량유생소D가이승고혈청개리자농도,대미、린무명현영향.결론 중、소제량유생소D대소서전렬선증생모형적간신공능、전해질미발현명현부면영향,대제량유생소D가능대혈청개리자농도、AST유일정영향.
Objective To investigate the safety of vitamin D on mouse model with benign prostate hyperplasia by analyzing the changes of serum biochemical indexes in benign prostate hyperplasia mice.Methods Mouse model with BPH was established by injecting testosterone.All test mice were randomly divided into different groups.Mice in different groups respectively received different oral doses of vitamin D with 0,0.2,1.0,and 5.0ug/kg·d for four weeks.Levels of serum electrolyte,triglyceride,cholesterol,hepatic function,renal function were detected.Results Levels of serum ALT,AST,BUN,Cr,TG,TC,P,Mg,Ca in mice treated with 0,0.2,1.0 and 5.0ug/kg of vitamin D were as follows:55.2±9.6,54.9±10.1,55.1±11.9,51.3±5.9;188.3±24.7,195.5±31.8,204.9±51.0,232.3±25.9;10.6±1.2,10.4±1.5,8.9±1.1,9.3±1.6;11.3±1.4,11.3±2.9,8.5±5.3,9.8±1.6;1.28±0.38,1.14±0.25.1.08±0.22,1.00±0.31;2.46±0.29,2.45±0.35,2.76±0.68,2.33±035;1.67±0.19,1.69±0.15,1.64±0.17,1.66±0.16;1.66±0.07,1.75±0.19,1.70±0.14,1.68±0.17;and 3.25±O.25,3.33±0.28,3.59±0.22,3.65±0.17.The level of serum AST and the concentration of Ca were upregulated BY high dose of vitamin D(P<0.01),whereas changes of serum Mg and P werenot found Conclusion No injury was found in liver and kidney function of mice with BPH treated with small doses of vitamin D.But the liver function of mice with BPH might be affected by high dose of vitamin D.
