国际外科学杂志
國際外科學雜誌
국제외과학잡지
INTERNATIONAL JOURNAL OF SURGERY
2012年
5期
309-313,封3
,共6页
薛栋%张同军%李新军%巩本刚%夏修良%陈雨信
薛棟%張同軍%李新軍%鞏本剛%夏脩良%陳雨信
설동%장동군%리신군%공본강%하수량%진우신
壶腹癌%Survivin%Bcl-2%免疫组织化学
壺腹癌%Survivin%Bcl-2%免疫組織化學
호복암%Survivin%Bcl-2%면역조직화학
Carcinoma of the ampulla of Vater%Survivin%Bcl-2%Immunohischemistry
目的 探讨Survivin和Bcl-2在壶腹癌组织中的表达及其临床意义.方法 用免疫组化EnVision法对40例壶腹癌组织进行Survivin和Bcl-2的检测,并对8例正常壶腹组织进行对照研究.结果 Survivin和Bcl-2在壶腹癌组织中的阳性表达率均显著高于正常壶腹组织(82.5％,72.5％ vs 0,12.5％),差异有统计学意义(P＜0.05).壶腹癌组织中Survivin和Bcl-2表达与患者性别、年龄、肿瘤大小、组织学类型、临床分期差异无统计学意义(P＞0.05)；Survivin和Bcl-2表达均与十二指肠浸润、胰腺浸润、淋巴结转移差异有统计学意义(P＜ 0.05)；经Spearman等级相关性分析表明,Survivin与Bcl-2表达呈正相关(r=0.647,P＜0.05).结论 Survivin和Bcl-2的高表达可能共同参与壶腹癌的发生、发展,联合检测Survivin和Bcl-2可能有助于判断壶腹癌的恶性程度及进展情况.
目的 探討Survivin和Bcl-2在壺腹癌組織中的錶達及其臨床意義.方法 用免疫組化EnVision法對40例壺腹癌組織進行Survivin和Bcl-2的檢測,併對8例正常壺腹組織進行對照研究.結果 Survivin和Bcl-2在壺腹癌組織中的暘性錶達率均顯著高于正常壺腹組織(82.5％,72.5％ vs 0,12.5％),差異有統計學意義(P＜0.05).壺腹癌組織中Survivin和Bcl-2錶達與患者性彆、年齡、腫瘤大小、組織學類型、臨床分期差異無統計學意義(P＞0.05)；Survivin和Bcl-2錶達均與十二指腸浸潤、胰腺浸潤、淋巴結轉移差異有統計學意義(P＜ 0.05)；經Spearman等級相關性分析錶明,Survivin與Bcl-2錶達呈正相關(r=0.647,P＜0.05).結論 Survivin和Bcl-2的高錶達可能共同參與壺腹癌的髮生、髮展,聯閤檢測Survivin和Bcl-2可能有助于判斷壺腹癌的噁性程度及進展情況.
목적 탐토Survivin화Bcl-2재호복암조직중적표체급기림상의의.방법 용면역조화EnVision법대40례호복암조직진행Survivin화Bcl-2적검측,병대8례정상호복조직진행대조연구.결과 Survivin화Bcl-2재호복암조직중적양성표체솔균현저고우정상호복조직(82.5％,72.5％ vs 0,12.5％),차이유통계학의의(P＜0.05).호복암조직중Survivin화Bcl-2표체여환자성별、년령、종류대소、조직학류형、림상분기차이무통계학의의(P＞0.05)；Survivin화Bcl-2표체균여십이지장침윤、이선침윤、림파결전이차이유통계학의의(P＜ 0.05)；경Spearman등급상관성분석표명,Survivin여Bcl-2표체정정상관(r=0.647,P＜0.05).결론 Survivin화Bcl-2적고표체가능공동삼여호복암적발생、발전,연합검측Survivin화Bcl-2가능유조우판단호복암적악성정도급진전정황.
Objective To study the expressions of Survivin and Bcl-2 in carcinoma of the ampulla of Vater and their clinical significance.Methods The expressions of Survivin and Bcl-2 proteins were tested by EnVision immunohistochemistry in 40 cases of ampullary carcinomas,and 8 cases of normal ampulla of rater as control.Results The positive expression of Survivin and Bcl-2 in the tissues from the ampullary carcinoma was significantly higher than that in the normal controls(82.5％,72.5％ vs 0％,12.5％,P ＜0.05).The expression of Survivin and Bcl-2 had no relations with the sex,age,tumor size,histological types,and clinical stages( P ＞ 0.05 ).The differences of the expression of Survivin and Bcl-2 in ampullary carcinoma of duodenal invasion,pancreatic invasion,and lymph node metastasis were significant(P ＜ 0.05) ; Significantly positive correlation was found between the expression of Survivin and Bcl-2 by using spearman correlation analysis( r =0.647,P ＜ 0.05 ).Conclusions Survivin and Bcl-2 may play an important role in tumorigenesis of ampullary carcinoma.Combined detection of Survivin and Bcl-2 may be useful to determine the degree of malignancy and the progress of the ampullary carcinoma.
