CAJ | 학술논문

白细胞介素-22(IL-22)是2000年发现的一种新型细胞因子,主要由活化的T1细胞和NK细胞分泌生成.其受体在人体皮肤、泌尿系统、消化系统及呼吸系统组织中均有较高的表达.研究发现IL-22不仅具有抗微生物感染、诱导急性炎性介质反应、防御及修复损伤、增强天然免疫等作用,最重要的它还能调节肿瘤细胞的增生、分化及凋亡过程,这为我们研究某些肿瘤的靶向治疗提供了新的启示.
백세포개소-22(IL-22)시2000년발현적일충신형세포인자,주요유활화적T1세포화NK세포분비생성.기수체재인체피부、비뇨계통、소화계통급호흡계통조직중균유교고적표체.연구발현IL-22불부구유항미생물감염、유도급성염성개질반응、방어급수복손상、증강천연면역등작용,최중요적타환능조절종류세포적증생、분화급조망과정,저위아문연구모사종류적파향치료제공료신적계시.
Interleukin-22 (IL-22) is a new kind of eytokine discovered in 2000. The major sources of IL-22 are activated T1 -cells and NK-cells. Tissue cells at outer body barriers, i.e. of the skin, kidney, the di-gestive and respiratory systems all highly express IL-22R or respond to IL-22. IL-22 functions by promoting the anti-microbial defense, inducing phase reactants, protecting against damage and enhancing natural immu-nity. Furthermore, IL-22 mediates the proliferation, differentiation and apoptesis in cancer cells, that gives us a new idea about tumor therapy.