CAJ | 학술논문

目的　保存精神分裂症特有的基因组资源。方法　采用Epstein Barr(EB)病毒转化技术，把患者外周血B淋巴细胞转化成永生类淋巴母细胞系。结果　建系150个，包括精神分裂症各型、同胞对、双胞胎、核心家庭、三代及三代以上家系构成永生细胞库。结论　精神分裂症患者基因组保存永生细胞库的建立，为我国精神分裂症分子水平发病机理的研究提供用之不竭的DNA资源。
목적　보존정신분렬증특유적기인조자원。방법　채용Epstein Barr(EB)병독전화기술，파환자외주혈B림파세포전화성영생류림파모세포계。결과　건계150개，포괄정신분렬증각형、동포대、쌍포태、핵심가정、삼대급삼대이상가계구성영생세포고。결론　정신분렬증환자기인조보존영생세포고적건립，위아국정신분렬증분자수평발병궤리적연구제공용지불갈적DNA자원。
Objective To preserve peculiar genomes resources of schizophrenic patients.Methods The permanent lymphoblastoid cell lines of schizophrenic patients were established by Epstein Barr virus transformation of peripheral blood B lymphocytes. Results The bank with 150 permanent cell lines from different types, sib-pair, twins and family lines of schizophrenia were established.Conclusion It is important to establish permanent lymphoblastoid cell bank of schizophenic and provide long- term DNA materials for study of schizophrenic pathogenesis in molecular level in our country.