CAJ | 학술논문

背景:密钙息治疗骨质疏松症疗效在临床上较为肯定,但因价格、应用方式等原因,使其应用受到一定限制.目的:为了探讨中医药治疗绝经后骨质疏松症远期疗效,客观评价补肾壮骨冲剂治疗绝经后骨质疏松症疗效.设计:随机对照实验研究.方法:采用随机分组,在3家医院将175例绝经后骨质疏松症患者,入选先后分成补肾壮骨冲剂组88例,密钙息组87例,并且另设67例作为对照组.治疗后观察其疼痛缓解情况并测定前臂骨密度及血清钙、磷和碱性磷酸酶等骨代谢生化指标,进行综合疗效分析.主要观察指标:治疗后观察其疼痛、前臂骨密度、血清钙、磷和碱性磷酸酶结果.结果:补肾壮骨冲剂组、密钙息组的总有效率分别为87.51%和89.66%.两组间无明显差异(x2=0.02,P＞0.05);两组与空白对照组(总有效率为32.84%)比较差异有显著性意义(x2=2.875～2.937,P＜0.05).结论:补肾壮骨冲剂与密钙息治疗绝经后骨质疏松症疗效相仿,而补肾壮骨冲剂有价格低廉、副作用少、服用方便等优势.
배경:밀개식치료골질소송증료효재림상상교위긍정,단인개격、응용방식등원인,사기응용수도일정한제.목적:위료탐토중의약치료절경후골질소송증원기료효,객관평개보신장골충제치료절경후골질소송증료효.설계:수궤대조실험연구.방법:채용수궤분조,재3가의원장175례절경후골질소송증환자,입선선후분성보신장골충제조88례,밀개식조87례,병차령설67례작위대조조.치료후관찰기동통완해정황병측정전비골밀도급혈청개、린화감성린산매등골대사생화지표,진행종합료효분석.주요관찰지표:치료후관찰기동통、전비골밀도、혈청개、린화감성린산매결과.결과:보신장골충제조、밀개식조적총유효솔분별위87.51%화89.66%.량조간무명현차이(x2=0.02,P＞0.05);량조여공백대조조(총유효솔위32.84%)비교차이유현저성의의(x2=2.875～2.937,P＜0.05).결론:보신장골충제여밀개식치료절경후골질소송증료효상방,이보신장골충제유개격저렴、부작용소、복용방편등우세.
BACKGROUND: The clinical therapeutic effectiveness of calcitonin is quite sure, but price and the method in application limit clinical application.OBJECTIVE: To objectively evaluate the therapeutic effect of Bushen Zhuanggu(tonify the kidney-yang, and strengthen the bone) medicament in the treatmeut of menopausal osteoporosis for discussing the long-term therapeutic effect of traditional Chinese medicine(TCM).DESIGN: A randomiaed control study.SETTING, PARTICIPANTS and INTERVENTIONS: Totally 175menopausal osteoporosis patients selected from 3 hospitals were randomly allocated into Bushen Zhuanggu medicament group( n =88) and calcitonin group( n = 87) and moreover, another 67 subjects were selected into control group. The conditions of pain relieve after therapy were observed. The osseous density of forearm was detected. The biochemical indexes of bone metabolism,such as serous calciun, serous phosphorate and ALP, were assayed. All results were collected for integrate therapeutic effectiveness analysis.MAIN OUTCOME MEASURES: Results of pain, serous calcium, serous phosphorate and ALP after treatment.RESULTS: The total effective rate in Bushen Zhuanggu medicament group and calcitonin group was 87.51% and 89.66% respectively with no significant difference(X2 = 0.02, P ＞ 0.05). However, there were differences between the two therapy groups and that of control group(total effective rate of 32.84% ) with statistical significances(x2 =2. 875-2. 937, P ＜ 0.05).CONCLUSION: There is similar therapeutic effectiveness of Bushen Zhuanggu medicament in the treatment of menopausal osteoporosis compared with calcitonin; however, Bushen zhuanggu medicament has the advantages of low price, less side effects and convenient application and so on.