CAJ | 학술논문

背景:对放射线单一危害的影响研究很多,但烟、茶和放射线联合作用因素对实验动物体质量及白细胞影响的研究文献报道较少.目的:观察吸烟、饮茶和放射线单独或联合作用对小鼠体质量及外周血白细胞计数的影响.设计:随机双盲法观察.地点和材料:取健康小鼠 64只,在滨州医学院毒理研究室作观察研究.干预:取健康小白鼠 64只 ,分成 8组, 7组小鼠单独或联合给予吸烟 7 d,饮茶 7 d和放射线照射( 2 Gy), 1组为空白对照组,观察小鼠体质量、外周血白细胞计数的变化.主要观察指标:实验 7 d后的小鼠体质量增长情况及实验末时外周血白细胞计数变化.结果:吸烟组小鼠体质量增长 [(- 1.63± 1.51) g]低于空白对照组 [(0.50± 1.65) g]( t=2.693, P《 0.05),放射组小鼠体质量增长 [(- 2.25± 1.20) g]低于空白对照组( t=3.821, P《 0.01),放射组小鼠白细胞计数 [(4.28± 1.71)× 109 L- 1]低于空白对照组 [(7.74± 1.97)× 109 L- 1]( t=3.761, P《 0.01).结论:吸烟和放射线均可抑制小鼠体质量增长,放射线可使小鼠外周血白细胞减少.烟茶对放射线引起的小鼠体质量和血液白细胞数下降无明显干预作用.
배경:대방사선단일위해적영향연구흔다,단연、다화방사선연합작용인소대실험동물체질량급백세포영향적연구문헌보도교소.목적:관찰흡연、음다화방사선단독혹연합작용대소서체질량급외주혈백세포계수적영향.설계:수궤쌍맹법관찰.지점화재료:취건강소서 64지,재빈주의학원독리연구실작관찰연구.간예:취건강소백서 64지 ,분성 8조, 7조소서단독혹연합급여흡연 7 d,음다 7 d화방사선조사( 2 Gy), 1조위공백대조조,관찰소서체질량、외주혈백세포계수적변화.주요관찰지표:실험 7 d후적소서체질량증장정황급실험말시외주혈백세포계수변화.결과:흡연조소서체질량증장 [(- 1.63± 1.51) g]저우공백대조조 [(0.50± 1.65) g]( t=2.693, P《 0.05),방사조소서체질량증장 [(- 2.25± 1.20) g]저우공백대조조( t=3.821, P《 0.01),방사조소서백세포계수 [(4.28± 1.71)× 109 L- 1]저우공백대조조 [(7.74± 1.97)× 109 L- 1]( t=3.761, P《 0.01).결론:흡연화방사선균가억제소서체질량증장,방사선가사소서외주혈백세포감소.연다대방사선인기적소서체질량화혈액백세포수하강무명현간예작용.
BACKGROUND:There were a lot of studies on the effects of hazards of single radioactive rays,but very few which reported the effects of joint-active factors,such as smoking,tea-drinking and radioactive on the experimental animal's mass and white blood cell(WBC). OBJECTIVE:To observe the effects of smoking,tea-drinking and radioactive rays on mouse's mass and WBC counting. DESIGN:Randomized and double blind observation. SETTING and MATERIALS:A total of 64 healthy mice were studied in the Lab of Toxicology in Binzhou Medical College. INTERVENTIONS:A total of 64 healthy mice were divided into 8 groups.Mice of 7 groups were given separately or combinedly smoking for 7 days,tea-drinking for 7 days and radioactive rays with 2 Gy respectively.In the blank control group,mass and white blood cell of the eight mice WBC counting were observed. MAIN OUTCOME MEASURES:Mass increasing after 7 days and WBC counting of mice at the end of experiment were observed. RESULTS:The increasing mass of smoking group[(- 1.63± 1.51) g] was lower than that of blank control group[(0.50± 1.65) g] (t=2.693,P< 0.05),and that of irradiation group[(- 2.25± 1.20) g] was lower than that of blank control group(t=3.821,P< 0.01).WBC counting in irradiation group[(4.28± 1.71)× 109 L- 1]was lower than that of the blank control group[(7.74± 1.97)× 109 L- 1](t=3.761,P< 0.01). CONCLUSION:Smoking can inhibit mouse's mass.Radioactive rays can decrease mouse's mass and WBC number.Smoking and tea-drinking don't have any obvious intervention in the decrease of mouse's mass and WBC.