中国行为医学科学
中國行為醫學科學
중국행위의학과학
2001年
1期
4-6
,共3页
龙大宏%李沃棠%许孟杰%姚志彬
龍大宏%李沃棠%許孟傑%姚誌彬
룡대굉%리옥당%허맹걸%요지빈
神经生长因子%老年性痴呆%学习记忆%老年鼠
神經生長因子%老年性癡呆%學習記憶%老年鼠
신경생장인자%노년성치태%학습기억%노년서
目的 探讨神经生长因子(NGF)对老年痴呆鼠学习记忆能力的影响。方法 切断老年SD大鼠左侧穹窿海马伞(FF),侧脑室注射NGF,用Morris水迷宫和Y迷宫测试正常组、损伤组和治疗组大鼠的学习记忆能力。结果 治疗组大鼠与损伤组相比较,治疗组平均逃避潜伏期缩短,原平台象限游泳距离和穿环次数增多,学会Y迷宫所需训练次数减少和正确反应次数增多,但未完全达到正常水平。结论 提示NGF能够改善老年FF损伤鼠学习记忆能力。
目的 探討神經生長因子(NGF)對老年癡呆鼠學習記憶能力的影響。方法 切斷老年SD大鼠左側穹窿海馬傘(FF),側腦室註射NGF,用Morris水迷宮和Y迷宮測試正常組、損傷組和治療組大鼠的學習記憶能力。結果 治療組大鼠與損傷組相比較,治療組平均逃避潛伏期縮短,原平檯象限遊泳距離和穿環次數增多,學會Y迷宮所需訓練次數減少和正確反應次數增多,但未完全達到正常水平。結論 提示NGF能夠改善老年FF損傷鼠學習記憶能力。
목적 탐토신경생장인자(NGF)대노년치태서학습기억능력적영향。방법 절단노년SD대서좌측궁륭해마산(FF),측뇌실주사NGF,용Morris수미궁화Y미궁측시정상조、손상조화치료조대서적학습기억능력。결과 치료조대서여손상조상비교,치료조평균도피잠복기축단,원평태상한유영거리화천배차수증다,학회Y미궁소수훈련차수감소화정학반응차수증다,단미완전체도정상수평。결론 제시NGF능구개선노년FF손상서학습기억능력。
Objective To study the effect of nerve growth factor on spatial learning and memory in aged rats with unilateral FF transection.Methods Aged male SD rats with left FF lesions received continuous infusion NGF or Cyt.C into the cerebroventricular space.One month after lesion,the learning and memory abilities were measured by Morris water maze and Y-maze test.Result NGF treatment group had significantly shortened in escape latency compared with lesioned group.The treatment group had significantly increased compare with lesioned one in the percentage of swim distance in platform quadrant,the number of crossing platform,the number of correct conditioned reflex activity. The treatment group had significantly decreased in number of trial compared with lesioned one.But the parameter of treatment group did not reach the levels of one of normal group.Conclusion It is showed NGF improved the ability of spatial learning and memory in aged rats with FF transection.