国际医药卫生导报
國際醫藥衛生導報
국제의약위생도보
INTERNATIONAL MEDICINE & HEALTH GUIDANCE NEWS
2012年
13期
1862-1864
,共3页
高血压前期%血清%尿酸%颈动脉粥样硬化
高血壓前期%血清%尿痠%頸動脈粥樣硬化
고혈압전기%혈청%뇨산%경동맥죽양경화
Prehypertension%Serum%Uric acid%Carotid atherosclerosis
目的 观察高血压前期患者血清尿酸(uA)水平的变化及其与颈动脉粥样硬化的病变关系,总结其临床应用价值.方法 选取我院2010年8月至2011年12月收治的高血压前期患者56例,设为观察组A；选取同期原发性高血压患者68例,设为观察组B:再选取同期血压正常的人70例,设为对照组.观察、比较三组血清中的uA水平、血脂水平、颈总动脉内膜中层厚度(IMT)及其相关性.结果 观察组A、B血清中的uA水平、低密度脂蛋白(LDL-C)、IMT与对照组比较,差异有统计学意义(P＜0.05)；观察组A、B间的IMT比较,差异有统计学意义(P＜0.05)；观察组A患者血清中的uA水平、IMT与患者的血压呈现出明显的正相关关系( r=0.47、0.46,P＜0.05)；血清中的uA水平与IMT也呈现出明显的正相关关系(r=0.51,P＜ 0.05).结论 高血压前期患者血清尿酸水平升高,颈总动脉内膜中层厚度也同步增高,并会随着uA的不断升高,发展为动脉粥样硬化的危险性也增高；因此,临床上应重视对高血压前期患者进行筛查及早期防治,这对减少动脉粥样硬化的发生具有重要的临床意义.
目的 觀察高血壓前期患者血清尿痠(uA)水平的變化及其與頸動脈粥樣硬化的病變關繫,總結其臨床應用價值.方法 選取我院2010年8月至2011年12月收治的高血壓前期患者56例,設為觀察組A；選取同期原髮性高血壓患者68例,設為觀察組B:再選取同期血壓正常的人70例,設為對照組.觀察、比較三組血清中的uA水平、血脂水平、頸總動脈內膜中層厚度(IMT)及其相關性.結果 觀察組A、B血清中的uA水平、低密度脂蛋白(LDL-C)、IMT與對照組比較,差異有統計學意義(P＜0.05)；觀察組A、B間的IMT比較,差異有統計學意義(P＜0.05)；觀察組A患者血清中的uA水平、IMT與患者的血壓呈現齣明顯的正相關關繫( r=0.47、0.46,P＜0.05)；血清中的uA水平與IMT也呈現齣明顯的正相關關繫(r=0.51,P＜ 0.05).結論 高血壓前期患者血清尿痠水平升高,頸總動脈內膜中層厚度也同步增高,併會隨著uA的不斷升高,髮展為動脈粥樣硬化的危險性也增高；因此,臨床上應重視對高血壓前期患者進行篩查及早期防治,這對減少動脈粥樣硬化的髮生具有重要的臨床意義.
목적 관찰고혈압전기환자혈청뇨산(uA)수평적변화급기여경동맥죽양경화적병변관계,총결기림상응용개치.방법 선취아원2010년8월지2011년12월수치적고혈압전기환자56례,설위관찰조A；선취동기원발성고혈압환자68례,설위관찰조B:재선취동기혈압정상적인70례,설위대조조.관찰、비교삼조혈청중적uA수평、혈지수평、경총동맥내막중층후도(IMT)급기상관성.결과 관찰조A、B혈청중적uA수평、저밀도지단백(LDL-C)、IMT여대조조비교,차이유통계학의의(P＜0.05)；관찰조A、B간적IMT비교,차이유통계학의의(P＜0.05)；관찰조A환자혈청중적uA수평、IMT여환자적혈압정현출명현적정상관관계( r=0.47、0.46,P＜0.05)；혈청중적uA수평여IMT야정현출명현적정상관관계(r=0.51,P＜ 0.05).결론 고혈압전기환자혈청뇨산수평승고,경총동맥내막중층후도야동보증고,병회수착uA적불단승고,발전위동맥죽양경화적위험성야증고；인차,림상상응중시대고혈압전기환자진행사사급조기방치,저대감소동맥죽양경화적발생구유중요적림상의의.
Objective To explore changes in serum uric acid ( UA ) level and its association with carotid atherosclerotic lesions in patients with prehypertension.Methods 56 patients with prehypertension were assigned to study group A,68 patients with essential hypertension were assigned to study group B,and 70 normotensive people were enrolled into control group.Serum levels of UA and lipids and carotid artery intima-media thickness ( IMT ) and their correlation were observed and compared among the three groups.Results IMT and Ievels of UA and LDL-C differed significantly between the control group and the study groups A and B ( P＜ 0.05 ); there was a significant difference in IMT between group A and group B ( P＜ 0.05 ).In study group A,UA level and IMT were positively associated with blood pressure ( r=-0.47,0.46,P ＜ 0.05 ); and UA level was positively related with IMT ( r=0.51,P ＜ 0.05 ).Conclusions Serum uric acid level and carotid artery intima-media thickness increase in patients with prehypertension; and the risk of developing atherosclerosis is elevated with an increase in uric acid.Therefore,attention should be paid to the screening and early prevention of prehypertension to reduce the occurrence of atherosclerosis,which has important clinical significance.
