中国医师杂志
中國醫師雜誌
중국의사잡지
JOURNAL OF CHINESE PHYSICIAN
2011年
8期
1041-1044
,共4页
张奇山%杨期明%李琳%江杨华
張奇山%楊期明%李琳%江楊華
장기산%양기명%리림%강양화
糖尿病,2型/遗传学%肽基二肽酶A/遗传学%多态现象,遗传
糖尿病,2型/遺傳學%肽基二肽酶A/遺傳學%多態現象,遺傳
당뇨병,2형/유전학%태기이태매A/유전학%다태현상,유전
Diabetes mellitus,type 2/GE%Peptidyl-dipeptidase A/GE%Polymorphism,genetic
目的 评估郴州地区汉族人群血管紧张素转化酶(angiotensin-converting enzyme，ACE)基因插入/缺失(insertion/deletion，I/D)多态性与2型糖尿病的关系。方法采用横断面研究方法，随机纳入340例对象，其中2型糖尿病患者128例，前糖尿病患者100例，非糖尿病者112例。用PCR法检测ACE基因I/D多态性，基因型分为II、ID或DD型。结果三组患者的年龄(X2=32.09，P ＜0.01)、BMI(X2=16.10,P＜0.01)、糖尿病家族史(X2=20.42,P＜0.01)和血清甘油三酯水平(F =21.289,P＜0.01)差异有统计学意义。三种基因型II、ID和DD的分布在2型糖尿病组为72例(56.3％)，52(40.6％)和4例(3.1％);在前糖尿病组为64例(64.0％)，30例(30.0％)和6例(6.0％);在非糖尿病组为81例(72.3％)，29例(25.9％)和2例(1.8％)例。ID+DD基因型与Ⅱ基因型2型糖尿病的患病比例差异有统计学意义(X2=6.68，P ＜0.05)。Logistic回归分析表明2型糖尿病的危险因素包括ACE基因I/D多态性、糖尿病家族史、BMI和血清甘油三酯浓度。结论ACE基因ID+ DD基因型与郴州地区社区汉族人群2型糖尿病的发病相关。
目的 評估郴州地區漢族人群血管緊張素轉化酶(angiotensin-converting enzyme，ACE)基因插入/缺失(insertion/deletion，I/D)多態性與2型糖尿病的關繫。方法採用橫斷麵研究方法，隨機納入340例對象，其中2型糖尿病患者128例，前糖尿病患者100例，非糖尿病者112例。用PCR法檢測ACE基因I/D多態性，基因型分為II、ID或DD型。結果三組患者的年齡(X2=32.09，P ＜0.01)、BMI(X2=16.10,P＜0.01)、糖尿病傢族史(X2=20.42,P＜0.01)和血清甘油三酯水平(F =21.289,P＜0.01)差異有統計學意義。三種基因型II、ID和DD的分佈在2型糖尿病組為72例(56.3％)，52(40.6％)和4例(3.1％);在前糖尿病組為64例(64.0％)，30例(30.0％)和6例(6.0％);在非糖尿病組為81例(72.3％)，29例(25.9％)和2例(1.8％)例。ID+DD基因型與Ⅱ基因型2型糖尿病的患病比例差異有統計學意義(X2=6.68，P ＜0.05)。Logistic迴歸分析錶明2型糖尿病的危險因素包括ACE基因I/D多態性、糖尿病傢族史、BMI和血清甘油三酯濃度。結論ACE基因ID+ DD基因型與郴州地區社區漢族人群2型糖尿病的髮病相關。
목적 평고침주지구한족인군혈관긴장소전화매(angiotensin-converting enzyme，ACE)기인삽입/결실(insertion/deletion，I/D)다태성여2형당뇨병적관계。방법채용횡단면연구방법，수궤납입340례대상，기중2형당뇨병환자128례，전당뇨병환자100례，비당뇨병자112례。용PCR법검측ACE기인I/D다태성，기인형분위II、ID혹DD형。결과삼조환자적년령(X2=32.09，P ＜0.01)、BMI(X2=16.10,P＜0.01)、당뇨병가족사(X2=20.42,P＜0.01)화혈청감유삼지수평(F =21.289,P＜0.01)차이유통계학의의。삼충기인형II、ID화DD적분포재2형당뇨병조위72례(56.3％)，52(40.6％)화4례(3.1％);재전당뇨병조위64례(64.0％)，30례(30.0％)화6례(6.0％);재비당뇨병조위81례(72.3％)，29례(25.9％)화2례(1.8％)례。ID+DD기인형여Ⅱ기인형2형당뇨병적환병비례차이유통계학의의(X2=6.68，P ＜0.05)。Logistic회귀분석표명2형당뇨병적위험인소포괄ACE기인I/D다태성、당뇨병가족사、BMI화혈청감유삼지농도。결론ACE기인ID+ DD기인형여침주지구사구한족인군2형당뇨병적발병상관。
Objective To determine the angiotensin-converting enzyme (ACE) insertion/deletion (I/D) polymorphism in Han ethnic patients with type 2 diabetes in Chenzhou area of Hunan province,and to assess the assoeiation between this polymorphism and diabetes.Methods This study was cross-sectional designed.Samples were taken by random sampling method from diabetes, prediabetes and euglycemia subjeers.ACE gene polymorphism I/D were examined by PCR.Genotype was classified as I1, ID, or DD based on positive or negative insertion/deletion allele.Results This study showed significant differences of ages (X2 =32.09, P ＜0.01), body mass index (BMI) (X2 =16.10, P ＜0.01), family history (X2 =20.42, P ＜0.01) and serum triglyceride (F =21.289, P ＜0.01) among three groups, and diabetes group tended to have higher value.Frequency of genotype II, ID, DD were 72(56.3％) ,52(40.6％) and 4(3.1％) in diabetes, 64(64.0％) ,30(30.0％) and 6(6.0％) in pre-diabetes subjects, 81 (72.3％),29(25.9％)和 2(1.8％) in euglycemia subjects, consecutively.Chi-square analysis showed statistically significant association between ID + DD vs.Ⅱ genotype and diabetes (x2 = 6.68, P ＜ 0.05).Logistic regression analysis showed four variables that significantly influence to diabetes, namely ACE gene polymorphism, family history of diabetes, BMI, and serum triglyceride level.Conclusions ACE ID + DD genotype had significant relationship with diabetes in Chenzhou Han ethnic population, Hunan province, China.
