CAJ | 학술논문

心房颤动是临床上最常见的一种心律失常，临床及实验均发现心房颤动中心房存在明显纤维化。心房纤维化被认为是发生心房颤动的结构基础，改变了心房的结构进而使心房功能受损。心房颤动心房纤维化的发生机制尚未完全明确。目前对心房颤动心房纤维化结构改变的研究发现：一系列细胞因子特别是肾素-血管紧张素系统、转化生长因子-β1、基质金属蛋白酶等在心房颤动及纤维化的发生、维持中作用明显。该文探讨了心房颤动心房纤维化的分子生物学发生机制及研究进展。
심방전동시림상상최상견적일충심률실상，림상급실험균발현심방전동중심방존재명현섬유화。심방섬유화피인위시발생심방전동적결구기출，개변료심방적결구진이사심방공능수손。심방전동심방섬유화적발생궤제상미완전명학。목전대심방전동심방섬유화결구개변적연구발현：일계렬세포인자특별시신소-혈관긴장소계통、전화생장인자-β1、기질금속단백매등재심방전동급섬유화적발생、유지중작용명현。해문탐토료심방전동심방섬유화적분자생물학발생궤제급연구진전。
Atrial fibrillation (AF) is the most common cardiac arrhythmia in clinical practice,but precise mechanisms that lead to the start and persistence of AF have not been clarified. It has been observed that Atrial fibrosis concurs with AF, a phenomenon that contributes to the resistance to restore and maintain sinus rhythm ( SR ). The promotion of fibrosis involes in a variety of signaling systems, such as angiotensin Ⅱ, transforming growth factor-β1 and matrix metalloproteinases. We have reviewed the current understanding of the mechanisms underlying atrial fibrosis and its progression in this paper.