CAJ | 학술논문

尽管联合抗病毒治疗,HIV仍能在淋巴细胞和单核细胞中持续存在.而且,即使体外研究证实HIV病毒颗粒nef、gp120和tat具有神经毒性,HIV相关痴呆症(HAD)的发生主要还是由于单核/巨噬细胞及与其相关的胶质细胞的间接免疫应答.因此,外周病毒库的循环单核细胞中的HIV在HAD发病机制中发挥着重要作用.针对循环单核细胞中HIV的导向治疗不仅有利于消灭外周病毒库,也有利于HAD及其他HIV并发症的防治.此文就单核细胞病毒库与HAD发病之间的关系进行了综述.
진관연합항병독치료,HIV잉능재림파세포화단핵세포중지속존재.이차,즉사체외연구증실HIV병독과립nef、gp120화tat구유신경독성,HIV상관치태증(HAD)적발생주요환시유우단핵/거서세포급여기상관적효질세포적간접면역응답.인차,외주병독고적순배단핵세포중적HIV재HAD발병궤제중발휘착중요작용.침대순배단핵세포중HIV적도향치료불부유리우소멸외주병독고,야유리우HAD급기타HIV병발증적방치.차문취단핵세포병독고여HAD발병지간적관계진행료종술.
It is well known that HIV in lymphoid and myeloid cells persists despite combination antiretroviral therapy. Although viral particles, such as nef, gp120 and tat are neurotoxic in vitro, the mechanisms of HIV associated dementia (HAD) likely involve a significant contribution from indirect immunological processes, including a prominent role for inflammatory pathways mediated by cells of the monocyte/macrophage lineage. Since monocytes are likely involved in trafficking virus to the brain, there is a strong mechanistic link underlying this discovery. Therefore, HIV in circulating monocytes plays a crucial role in developing HAD. The therapy directed to HIV in monocyte may not only help eliminating the virus in peripheral criculation, but also conducive to the prevention and treatment of HAD and other HIV complications. The relation between HAD and monocytic virus reservoir is reviewed in this article.