CAJ | 학술논문

背景年龄相关性黄斑变性(AMD)的早期诊断和治疗至关重要.以往对AMD的诊断主要参照荧光素眼底血管造影(FFA)和光学相干断层扫描(OCT),但眼底自发荧光技术(FAF)无需注射造影剂,大大优化了诊断过程.目的观察萎缩性AMD的FAF特征.方法 28例39眼萎缩性AMD按照陈松的分类方法进行分组,应用激光共焦扫描检眼镜HRA2获得所有患者的FAF平均图像,并与眼底照相或FFA结果进行比较.结果萎缩性AMD的FAF信号异常增高或降低区域与眼底的改变可能对应或不对应.萎缩性AMD萎缩前期FAF改变包括轻微改变、局灶性、片状、线性、花边样、网状和斑点状增强等7种形态.萎缩性AMD萎缩期地图状萎缩区呈边界清晰的低FAF区,其交界区表现为正常FAF、FAF带状增强或弥漫性增强;非地图状萎缩呈边界不清的低FAF区,其交界区FAF弥漫性增强.结论 FAF成像技术为萎缩性AMD的诊断提供了一种新的非侵入性检查手段.
배경년령상관성황반변성(AMD)적조기진단화치료지관중요.이왕대AMD적진단주요삼조형광소안저혈관조영(FFA)화광학상간단층소묘(OCT),단안저자발형광기술(FAF)무수주사조영제,대대우화료진단과정.목적관찰위축성AMD적FAF특정.방법 28례39안위축성AMD안조진송적분류방법진행분조,응용격광공초소묘검안경HRA2획득소유환자적FAF평균도상,병여안저조상혹FFA결과진행비교.결과위축성AMD적FAF신호이상증고혹강저구역여안저적개변가능대응혹불대응.위축성AMD위축전기FAF개변포괄경미개변、국조성、편상、선성、화변양、망상화반점상증강등7충형태.위축성AMD위축기지도상위축구정변계청석적저FAF구,기교계구표현위정상FAF、FAF대상증강혹미만성증강;비지도상위축정변계불청적저FAF구,기교계구FAF미만성증강.결론 FAF성상기술위위축성AMD적진단제공료일충신적비침입성검사수단.
Background The early diagnosis and treatment is vital for the age-related macular degeneration (AMD).Previous examining methods were fundus fluorescein angiography(FFA)and optical coherence tomography (OCT).However,a new diagnostic technique,fundus autofluorescence(FAF),is applying in ophthalmology.objective This study was to observe the FAF characteristics of atrophic AMD. Methods Thirty-nine eyes of 28 patients with atrophic AMD were diagnosed and collected in our hospital and classified based on the criteria of Chen Song.FAF was performed by a confocal scanning laser ophthalmoscope(Heidelberg Retina Angiograph 2,HRA2).Characteristics of FAF images were compared with FFA images or color fundus photographs.Written informed consent was obtained from each patient prior to the examination. Results Areas with abnormal increased or decreased FAF signals were consisted or unconsisted with funduscopically visible alterations.Seven manifestations of FAF were found in the eyes with preatrophic stage of atrophic AMD,including slight change,focal increase pattern,patchy pattern,linear pattern,lacelike pattern,reticular pattern,and speckled pattern.In atrophic stage of atrophic AMD,geographic atrophy showed a well-defined hypoautofluorescence area;while non-geographic atrophy showed a ill-defined hypoautofluorescence area.There were three abnormal FAF patterns(focal,band and diffuse)in the junctional zone of geographic atrophy and diffuse pattern in the junctional zone of non-geographic atrophy. Conclusion FAF imaging is helpful for the diagnosis of atrophic AMD as a new non-invasive technique.