CAJ | 학술논문

目的观察反复发作抑郁症患者前扣带回、额叶执行功能在时间空间序列的变化特征.方法 18例反复发作抑郁症患者及21名年龄、性别、受教育年匹配的健康对照入组,利用脑磁图检测受试者在完成Stroop字色干扰测试时前扣带回、额叶功能的实时改变.结果 1.与对照组相比,患者组完成Stroop字色干扰测试时激活增强的脑区依次为(t代表激活强度):(1)100～ 200ms:右前扣带回(t=1.81)、双侧额内侧同(t=l.91,t=1.86)、左额上回(t=1.79)、右额中回(t=1.82)、右额下回(t=1.82)(2)200～300ms:左前扣带回(t=1.82)；(3)250 ～350 m:左前扣带同(t=2.67)、左额内侧同(t=2.43)、左额下回(t=1.91)；(4)300～400ms:左前扣带回(t=2.26)、双侧额下回(t=1.97,t=2.66)、左额内侧回(t=2.35)；(5)350 ～450ms:左前扣带回(t=2.02)、左额内侧回(t=2.00)、双侧额下回(t=1.74,t=1.78)；(6)400 ～ 500 ms:左前扣带回(t=2.01)、左额内侧回(t=1.97)；2.与对照组相比,患者组完成Stroop字色干扰测试时激活减弱的脑区为:200～300 ms左额中回(t=1.79)、左额上回(t=1.76).结论反复发作抑郁症患者前扣带回、额叶脑区存在时间和空间序列双层次的激活紊乱.
목적 관찰반복발작억욱증환자전구대회、액협집행공능재시간공간서렬적변화특정.방법 18례반복발작억욱증환자급21명년령、성별、수교육년필배적건강대조입조,이용뇌자도검측수시자재완성Stroop자색간우측시시전구대회、액협공능적실시개변.결과 1.여대조조상비,환자조완성Stroop자색간우측시시격활증강적뇌구의차위(t대표격활강도):(1)100～ 200ms:우전구대회(t=1.81)、쌍측액내측동(t=l.91,t=1.86)、좌액상회(t=1.79)、우액중회(t=1.82)、우액하회(t=1.82)(2)200～300ms:좌전구대회(t=1.82)；(3)250 ～350 m:좌전구대동(t=2.67)、좌액내측동(t=2.43)、좌액하회(t=1.91)；(4)300～400ms:좌전구대회(t=2.26)、쌍측액하회(t=1.97,t=2.66)、좌액내측회(t=2.35)；(5)350 ～450ms:좌전구대회(t=2.02)、좌액내측회(t=2.00)、쌍측액하회(t=1.74,t=1.78)；(6)400 ～ 500 ms:좌전구대회(t=2.01)、좌액내측회(t=1.97)；2.여대조조상비,환자조완성Stroop자색간우측시시격활감약적뇌구위:200～300 ms좌액중회(t=1.79)、좌액상회(t=1.76).결론 반복발작억욱증환자전구대회、액협뇌구존재시간화공간서렬쌍층차적격활문란.
Objective To investigate the variation of executive function of fronto-cingulate cortex in spatio-temporal sequence in recurrent depressed patients.Methods Eighteen recurrent depressed patients and twenty-one age-,gender- and education- matched healthy controls were involved in the Stroop word-color interference test to detect the executive function of anterior cingulate and prefrontal regions by magnetoencephaloraphy scanning.Results 1.Compared to healthy controls,the increased activation of brain regions in depressed patients during different time periods were separately shown as follows( t represents activation strength):( 1 ) 100 ～ 200 ms:the right anterior cingulate gyrus ( t =1.81,T value means activation strength),the bilateral medial frontal gyrus ( t =1.91,t =1.86),the left superior frontal gyms( t =1.79 ),the right middle frontal gyrus( t =1.82 ),the right inferior frontal gyrus ( t =1.82 ).( 2 ) 200 ～ 300 ms:the left anterior cingulate gyrus ( t =1.82 ).( 3 ) 250 ～ 350 ms:the left anterior cingulate gyrus ( t =2.67 ),the left medial frontal gyrus ( t =2.43 ),the left inferior frontal gyrus ( t=1.91 ).(4)300 ～400ms:the left anterior frontal gyrus(t=2.26),the bilateral inferior gyrus( t=1.97,t=2.66),the left medial frontal gyrus(t=2.35).(5)350 ～450ms:the left anterior cingulate gyrus(t=2.02),the left medial frontal gyrus ( t =2.00),the bilateral inferior frontal gyrus ( t =1.74,t =1.78 ).( 6 ) 400 ～ 500 ms:the left anterior cingulate gyrus( t=2.01 ),the left medial frontal gyrus( t =1.97).2.Compared to healthy controls,patients showed decreased activation in the left middle frontal gyms ( t =1.79) and the left superior gyrus(t =1.76) in 200 ～ 300 ms.Conclusion Executive dysfunction is reflected in depressed patients with the activation inefficiency in anterior cingulate and prefrontal regions in spatio-temporal sequence.