CAJ | 학술논문

目的探讨吗啡联合间苯三酚在急性肾绞痛治疗中的疗效.方法将120例急性肾绞痛患者按随机数字表法分为A、B、C三组,每组40例.A组给予0.9%氯化钠100 ml+间苯三酚80 mg静脉滴注及吗啡9 mg分3次静脉推注,B组给予0.9%氯化钠100 ml+间苯三酚80 mg静脉滴注,C组给予0.9%氯化钠100 ml静脉滴注及吗啡9 mg分3次静脉推注.分别于给药后10、20、40min观察镇痛效果及其不良反应.结果给药后20 min和40 min时,A组总有效率[82.5%(33/40)、95.0%(38/40)]明显高于B组[62.5%(25/40)、80.0%(32/40)]和C组[60.0%(24/40)、77.5%(31/40)](P＜0.05),疼痛缓解率也明显高于B组和C组(P＜0.05).A组在给药后20 min和加min时的总有效率和疼痛缓解率比较差异无统计学意义(P＞0.05).A组除1例患者出现恶心呕吐外,无疼痛加重及严重呼吸抑制等不良反应.结论吗啡分次注射联用间苯三酚静脉滴注治疗急性肾绞痛具有起效快、效果显著、安全等优点.
목적 탐토마배연합간분삼분재급성신교통치료중적료효.방법 장120례급성신교통환자안수궤수자표법분위A、B、C삼조,매조40례.A조급여0.9%록화납100 ml+간분삼분80 mg정맥적주급마배9 mg분3차정맥추주,B조급여0.9%록화납100 ml+간분삼분80 mg정맥적주,C조급여0.9%록화납100 ml정맥적주급마배9 mg분3차정맥추주.분별우급약후10、20、40min관찰진통효과급기불량반응.결과 급약후20 min화40 min시,A조총유효솔[82.5%(33/40)、95.0%(38/40)]명현고우B조[62.5%(25/40)、80.0%(32/40)]화C조[60.0%(24/40)、77.5%(31/40)](P＜0.05),동통완해솔야명현고우B조화C조(P＜0.05).A조재급약후20 min화가min시적총유효솔화동통완해솔비교차이무통계학의의(P＞0.05).A조제1례환자출현악심구토외,무동통가중급엄중호흡억제등불량반응.결론 마배분차주사련용간분삼분정맥적주치료급성신교통구유기효쾌、효과현저、안전등우점.
Objective To evaluate the efficacy of multiple injection of morphine combined with phloroglucinol in the treatment of renal colic. Methods One hundred and twenty patients with severe renal colic were equally divided into three groups by random digits table,with 40 cases each group. The group A was administrated with physiological saline 100 ml and phloroglucinol 80 mg intervenous drop infusion combined with morphine 9 mg intravenous injection fractionated into three times, and the group B was administrated with physiological saline 100 ml and phloroglucinol 80 mg intervenous drop infusion,and the group C was administrated with physiological saline 100 ml intervenous drop infusion and morphine 9 mg intravenous injection fractionated into three times. At 10,20 and 40 min after administration, the antalgic efficacy of three groups were analyzed as well as the side effect. Results At 20 min and 40 min both of the total efficacy rates in group A[82.5%(33/40),95.0%(38/40)] were higher than those in group B [62.5%(25/40),80.0%(32/40)] and group C [60.0%(24/40),77.5%(31/40)] (P＜ 0.05),and the colic-exclusion rate in group A was also higher than that in group B and group C (P ＜ 0.05). The difference of the efficacy rates in group A in these two time-points had no statistical significance (P ＞0.05). No increased pain occurred in group A except 1 case of vomiting. Conclusion Multiple injection of morphine combined with phloroglucinol is quick, effective and safe in the early treatment of renal colic.