中华器官移植杂志
中華器官移植雜誌
중화기관이식잡지
CHINESE JOURNAL OF ORGAN TRANSPLANTATION
2009年
1期
40-42
,共3页
许龙根%韩澍%刘永%王洪伟%杨亦荣%邱丰%彭万岭%唐礼功%傅晶%金丽明%朱晓峰%丁献凡%朱有华
許龍根%韓澍%劉永%王洪偉%楊亦榮%邱豐%彭萬嶺%唐禮功%傅晶%金麗明%硃曉峰%丁獻凡%硃有華
허룡근%한주%류영%왕홍위%양역영%구봉%팽만령%당례공%부정%금려명%주효봉%정헌범%주유화
肾移植%妊娠%分娩%儿童
腎移植%妊娠%分娩%兒童
신이식%임신%분면%인동
Kidney transplantation%Pregnancy%Parturition%Child
目的 探讨女性肾移植受者术后生育对子代、移植肾及自身健康的影响.方法 回顾分析8个器官移植中心自1989年8月至2007年2月的资料,共有22例女性肾移植受者术后妊娠,并各生育子女1名.由专人负责收集、整理受者及其子女的资料,包括受者的年龄、病程、肾移植时间、免疫抑制剂的应用、结婚及孕产时间、妊娠和分娩情况、子女出生情况、喂养方式等,并对其中的18名子女进行了体格检查,记录其身高和体重.结果 22例生育时的年龄为(27.8±2.7)岁,分娩时间为术后(35.1±13.2)个月,孕产期问免疫抑制方案为环孢素A(或他克莫司)、硫唑嘌呤(或霉酚酸酯)和泼尼松联用.其中21例为剖宫产,1例为自然分娩;6名(27.3%)为早产,其余为足月产.22名子女出生时体重为(2944±585)g,均人工喂养,现年龄最大者为18岁,最小者为8个月.3岁、4岁和5岁者的体重分别为(15.2±1.3)kg、(17.0±0.9)kg和(17.8±0.4)kg,身高分别为(99.0±3.6)cm、(106.4±1.3)cm和(109.5±0.7)cm,其他年龄段因样本数太少,未行统计.未发现明显畸形.22例受者在孕产期间并发高血压9例次,肾功能异常和蛋白尿各5例次,肺部感染和心力衰竭各4例次,尿路感染3例次,6例移植肾功能丧失,2例因肺部感染、心力衰竭死亡,1例因慢性排斥反应、移植肾功能丧失、心力衰竭死亡.结论 女性肾移植受者术后若情况允许,可以生育,但有时可对移植肾及自身健康有一定的影响,整个妊娠、生育过程应有产科、移植科以及心内科等医生共同参与指导.
目的 探討女性腎移植受者術後生育對子代、移植腎及自身健康的影響.方法 迴顧分析8箇器官移植中心自1989年8月至2007年2月的資料,共有22例女性腎移植受者術後妊娠,併各生育子女1名.由專人負責收集、整理受者及其子女的資料,包括受者的年齡、病程、腎移植時間、免疫抑製劑的應用、結婚及孕產時間、妊娠和分娩情況、子女齣生情況、餵養方式等,併對其中的18名子女進行瞭體格檢查,記錄其身高和體重.結果 22例生育時的年齡為(27.8±2.7)歲,分娩時間為術後(35.1±13.2)箇月,孕產期問免疫抑製方案為環孢素A(或他剋莫司)、硫唑嘌呤(或黴酚痠酯)和潑尼鬆聯用.其中21例為剖宮產,1例為自然分娩;6名(27.3%)為早產,其餘為足月產.22名子女齣生時體重為(2944±585)g,均人工餵養,現年齡最大者為18歲,最小者為8箇月.3歲、4歲和5歲者的體重分彆為(15.2±1.3)kg、(17.0±0.9)kg和(17.8±0.4)kg,身高分彆為(99.0±3.6)cm、(106.4±1.3)cm和(109.5±0.7)cm,其他年齡段因樣本數太少,未行統計.未髮現明顯畸形.22例受者在孕產期間併髮高血壓9例次,腎功能異常和蛋白尿各5例次,肺部感染和心力衰竭各4例次,尿路感染3例次,6例移植腎功能喪失,2例因肺部感染、心力衰竭死亡,1例因慢性排斥反應、移植腎功能喪失、心力衰竭死亡.結論 女性腎移植受者術後若情況允許,可以生育,但有時可對移植腎及自身健康有一定的影響,整箇妊娠、生育過程應有產科、移植科以及心內科等醫生共同參與指導.
목적 탐토녀성신이식수자술후생육대자대、이식신급자신건강적영향.방법 회고분석8개기관이식중심자1989년8월지2007년2월적자료,공유22례녀성신이식수자술후임신,병각생육자녀1명.유전인부책수집、정리수자급기자녀적자료,포괄수자적년령、병정、신이식시간、면역억제제적응용、결혼급잉산시간、임신화분면정황、자녀출생정황、위양방식등,병대기중적18명자녀진행료체격검사,기록기신고화체중.결과 22례생육시적년령위(27.8±2.7)세,분면시간위술후(35.1±13.2)개월,잉산기문면역억제방안위배포소A(혹타극막사)、류서표령(혹매분산지)화발니송련용.기중21례위부궁산,1례위자연분면;6명(27.3%)위조산,기여위족월산.22명자녀출생시체중위(2944±585)g,균인공위양,현년령최대자위18세,최소자위8개월.3세、4세화5세자적체중분별위(15.2±1.3)kg、(17.0±0.9)kg화(17.8±0.4)kg,신고분별위(99.0±3.6)cm、(106.4±1.3)cm화(109.5±0.7)cm,기타년령단인양본수태소,미행통계.미발현명현기형.22례수자재잉산기간병발고혈압9례차,신공능이상화단백뇨각5례차,폐부감염화심력쇠갈각4례차,뇨로감염3례차,6례이식신공능상실,2례인폐부감염、심력쇠갈사망,1례인만성배척반응、이식신공능상실、심력쇠갈사망.결론 녀성신이식수자술후약정황윤허,가이생육,단유시가대이식신급자신건강유일정적영향,정개임신、생육과정응유산과、이식과이급심내과등의생공동삼여지도.
Objective To evaluate the influence of bearing by female recipients after renal transplantation on their offspring, renal grafts and their health. Methods During Aug. 1989 to Feb. 2007, 22 female renal transplant recipients each gave birth to 1 child. The following data were recorded: age of recipients, course of disease, time of transplantation, immunosuppressive agents, time of marriage and pregnancy, the state of parturition, births of offspring, the way of infant feeding, etc. Eighteen offspring received physical examination, and their height and weight were recorded. Results Twenty-two female recipients had childbirth at the age of 27.8±2.7 (35.1±13.2 months after transplantation). Cyclosporine (CsA), azathioprine (or mycophenolate mofetil) and prednisone were used to prevent reject reaction. Twenty-two recipients had cesarean section, and only 1 recipient had natural childbirth. Six children (27.30%) were preterm birth, and all others were term-birth. During the perinatal stage, there were several pregnancy complications, including chronic hypertension (9 cases), renal function dysfunction and proteinuria (cach 5 cases), pulmonary infection and heart failure (each 4 cases), urinary tract infections (3 cases), and graft loss (6 cases). Two of 22 recipients died from pulmonary infection and heart failure, and 1 from chronic rejection, renal failure and heart failure. Conclusion Bearing by female recipients after renal transplantation may not have significant effects on the development of their offspring, but would have negative effects on recipients and renal grafts.
