中华医学杂志
中華醫學雜誌
중화의학잡지
National Medical Journal of China
2010年
37期
2607-2610
,共4页
王金高%孔德全%张自立%黄继义%俞祥玫%杨成彬%潘晓文%黄妍
王金高%孔德全%張自立%黃繼義%俞祥玫%楊成彬%潘曉文%黃妍
왕금고%공덕전%장자립%황계의%유상매%양성빈%반효문%황연
心脏骤停%心肺复苏术%血栓溶解疗法%D-二聚体
心髒驟停%心肺複囌術%血栓溶解療法%D-二聚體
심장취정%심폐복소술%혈전용해요법%D-이취체
Heart arrest%Cardiopulmonary resuscitation%Thrombolytic therapy%D-dimer
目的 探讨D-二聚体对心肺复苏(CPR)患者溶栓治疗的临床指导意义.方法 选择有自主循环恢复(ROSC)的CPR患者,按<2005国际CPR与心血管急救指南>进行复苏治疗,ROSC后,患者仍昏迷不醒、生命体征不稳,予颅脑CT及胸部CT检查,排除颅内出血、主动脉夹层、气胸等溶栓治疗禁忌证,共有47例患者入选,分为A、B、C 3组,A、B组经家属同意并签字后进行溶栓治疗,于溶栓前、溶栓1、2、4、8、12 h,检测外周静脉血中D-二聚体(D-Dimer).A组(17例):溶栓前D-二聚体≥512 μg/L;B组(14例):溶栓前D-二聚体<512μg/L;C组(16例)家属拒绝溶栓治疗的患者,不论D-二聚体升高与否,作为对照组.对各组患者-般资料、D-二聚体、治愈率、格拉斯哥昏迷评分(GCS)进行统计学分析.结果 A组D-二聚体于溶栓1 h即明显升高(P<0.05),溶栓2 h达峰值,之后逐渐下降,最终治愈率达67%,高于B、C组,差异有统计学意义(P<0.05);溶栓24 h GCS高于B、C组,差异有统计学意义(P<0.05).B组D-二聚体溶栓4 h内基本不变(P>0.05),溶栓8 h后逐渐下降(P<0.05),治愈率较低,溶栓24 h GCS无明显升高(P>0.05);C组为对照组,未进行溶栓治疗,治愈率及ROSC24 h GCS均较低.结论 CPR患者ROSC后,部分患者D-二聚体(≥512μg/L)明显升高,其心脏骤停可能与血栓栓塞、循环系统血栓形成、血液流变学异常等因素有密切的关系,在初步排除溶栓治疗的绝对禁忌证后,对这部分患者进行溶栓治疗,开通梗塞的血管,改善血流循环,解除心脏骤停的病因,从而提高了CPR患者的最终治愈率.部分患者D-二聚体(<512μg/L)无明显升高,考虑非血栓栓塞性疾病所致的心脏骤停,这时溶栓治疗不能改善患者的病情,也没有最终提高患者的治愈率,失去了溶栓治疗的意义.
目的 探討D-二聚體對心肺複囌(CPR)患者溶栓治療的臨床指導意義.方法 選擇有自主循環恢複(ROSC)的CPR患者,按<2005國際CPR與心血管急救指南>進行複囌治療,ROSC後,患者仍昏迷不醒、生命體徵不穩,予顱腦CT及胸部CT檢查,排除顱內齣血、主動脈夾層、氣胸等溶栓治療禁忌證,共有47例患者入選,分為A、B、C 3組,A、B組經傢屬同意併籤字後進行溶栓治療,于溶栓前、溶栓1、2、4、8、12 h,檢測外週靜脈血中D-二聚體(D-Dimer).A組(17例):溶栓前D-二聚體≥512 μg/L;B組(14例):溶栓前D-二聚體<512μg/L;C組(16例)傢屬拒絕溶栓治療的患者,不論D-二聚體升高與否,作為對照組.對各組患者-般資料、D-二聚體、治愈率、格拉斯哥昏迷評分(GCS)進行統計學分析.結果 A組D-二聚體于溶栓1 h即明顯升高(P<0.05),溶栓2 h達峰值,之後逐漸下降,最終治愈率達67%,高于B、C組,差異有統計學意義(P<0.05);溶栓24 h GCS高于B、C組,差異有統計學意義(P<0.05).B組D-二聚體溶栓4 h內基本不變(P>0.05),溶栓8 h後逐漸下降(P<0.05),治愈率較低,溶栓24 h GCS無明顯升高(P>0.05);C組為對照組,未進行溶栓治療,治愈率及ROSC24 h GCS均較低.結論 CPR患者ROSC後,部分患者D-二聚體(≥512μg/L)明顯升高,其心髒驟停可能與血栓栓塞、循環繫統血栓形成、血液流變學異常等因素有密切的關繫,在初步排除溶栓治療的絕對禁忌證後,對這部分患者進行溶栓治療,開通梗塞的血管,改善血流循環,解除心髒驟停的病因,從而提高瞭CPR患者的最終治愈率.部分患者D-二聚體(<512μg/L)無明顯升高,攷慮非血栓栓塞性疾病所緻的心髒驟停,這時溶栓治療不能改善患者的病情,也沒有最終提高患者的治愈率,失去瞭溶栓治療的意義.
목적 탐토D-이취체대심폐복소(CPR)환자용전치료적림상지도의의.방법 선택유자주순배회복(ROSC)적CPR환자,안<2005국제CPR여심혈관급구지남>진행복소치료,ROSC후,환자잉혼미불성、생명체정불은,여로뇌CT급흉부CT검사,배제로내출혈、주동맥협층、기흉등용전치료금기증,공유47례환자입선,분위A、B、C 3조,A、B조경가속동의병첨자후진행용전치료,우용전전、용전1、2、4、8、12 h,검측외주정맥혈중D-이취체(D-Dimer).A조(17례):용전전D-이취체≥512 μg/L;B조(14례):용전전D-이취체<512μg/L;C조(16례)가속거절용전치료적환자,불론D-이취체승고여부,작위대조조.대각조환자-반자료、D-이취체、치유솔、격랍사가혼미평분(GCS)진행통계학분석.결과 A조D-이취체우용전1 h즉명현승고(P<0.05),용전2 h체봉치,지후축점하강,최종치유솔체67%,고우B、C조,차이유통계학의의(P<0.05);용전24 h GCS고우B、C조,차이유통계학의의(P<0.05).B조D-이취체용전4 h내기본불변(P>0.05),용전8 h후축점하강(P<0.05),치유솔교저,용전24 h GCS무명현승고(P>0.05);C조위대조조,미진행용전치료,치유솔급ROSC24 h GCS균교저.결론 CPR환자ROSC후,부분환자D-이취체(≥512μg/L)명현승고,기심장취정가능여혈전전새、순배계통혈전형성、혈액류변학이상등인소유밀절적관계,재초보배제용전치료적절대금기증후,대저부분환자진행용전치료,개통경새적혈관,개선혈류순배,해제심장취정적병인,종이제고료CPR환자적최종치유솔.부분환자D-이취체(<512μg/L)무명현승고,고필비혈전전새성질병소치적심장취정,저시용전치료불능개선환자적병정,야몰유최종제고환자적치유솔,실거료용전치료적의의.
Objective To investigate the clinical significance of D-dimer contents in peripheral blood for monitoring the efficacy of thrombolytic therapy in patients with return of spontaneous circulation (ROSC) of cardiopulmonary resuscitation ( CPR ) cardiopulmonary resuscitation after cardiac arrest. Methods Forty-seven patients with sudden cardiac arrest received CPR according to 2005 American Heart Association (AHA) guidelines for CPR and emergency cardiovascular care (ECC). At the early stage of ROSC, those patients underwent head and breast CT scan if they were in a state of unconsciousness and had unstable vital signs. If intracranial hemorrhage, dissection of aorta and pneumothorax were rule out, and those patients who maintained blood circulation for over 24 hours were included. The expression of D-dimer contents in peripheral blood was determined at 0, 1, 2, 4, 8, 12 h after CPR in all patients. And the patients were randomly divided into control and experiment groups. Prior to thrombolysis, the patients whose D-dimer more than 512 μg/L were classified as Group A (n = 17 ); those whose D-dimer below 512 μg/L Group B ( n = 14); and the remaining control group whose family members refused thrombolytic therapy Group C (n = 16). The general data, Glasgow coma scale, survival rate and the change of D-dimer in peripheral blood were analyzed. Results In Group A, D-dimer level began to increase significantly at CPR 1 hour. It peaked at CPR 2 hours then decreased gradually. The final survival rate was 67%. The survival rate and CCS were higher than those of Groups B and C. In Group B, the D-dimer concentrations began to increase gradually at CPR1 hour, peaked at CPR 12 hours and then decreased. The survival rate and GCS was lower than those of Group A and similar to those of Group C. Group C was control group with no thrombolysis. Conclusion For those ROSC patients with D-dimer concentrations significantly higher than usual, the pathogenesis of cardiac arrest may be concerned with thromboembolism, thrombosis in circulatory system and hyperviscosity. After an initiation of thrombolytic therapy, blocked blood vessels are recanalized,blood circulation improves and the cause of cardiac arrest is removed. Thus their survival rate becomes better. For those with D-dimer concentrations no higher than usual, the cause of cardiac arrest is not concerned with thromboembolism, thrombolytic therapy can not improve the patient outcome. And the final survival rate remains unchanged. The significance of thrombolytic therapy is none.